Clinical Characteristics And Laboratory Analysis Of EB Virus Infected Children

Objective: After EB virus(Epstein-Barr Virus,EBV)infection,the clinical manifestations are complicated,which makes clinical diagnosis difficult.Analyze the clinical characteristics and related laboratory tests of children with EB virus infection to provide evidence for early diagnosis and treatmentMethods: The data of 135 hospitalized children diagnosed with Epstein-Barr virus infection in the pediatrics department of our hospital from July 2019 to January 2021 were collected.135 children with Epstein-Barr virus infection were classified according to the diagnostic criteria of infectious mononucleosis(IM)The IM group and the nonIM group.There are 41 cases in the IM group and 94 cases in the non-IM group.Compare the general information(gender,age,season of onset)and clinical characteristics(clinical manifestations,heat history,heat peak)of the two groups.And related laboratory tests(EB virus load,blood routine,liver function,lactate dehydrogenase(LDH),C-reactive proteins(CRP),immunoglobulin,T cell subgroups)The change situation.Results:(1)There were 41 cases in the IM group,including 21 males and 20 females,with a male to female ratio of 1.05:1;in the non-IM group,94 cases,with 53 males and41 females,with a male to female ratio of 1.29:1.The proportions of infants,preschool,school age,and adolescence in the IM group were 51.2%,34.1%,9.8%,and 4.9%,respectively.The proportions of infants,preschool,school age,and adolescence in the non-IM group were 51.06%,29.79%,14.89%,4.26%,the high incidence ages of the two groups were both infants and toddlers;the onset season of the two groups was mainly summer and autumn;there was no significant difference in gender,age composition,and season of onset between the two groups.(2)In the IM group,tonsillar enlargement,tonsil white discharge,lymphadenopathy and eyelid edema accounted for higher proportions than those in the non-IM group(P<0.05);the non-IM group had a higher heat peak than the IM group(P<0.05);The proportion of cough in the IM group was higher than that in the IM group(P<0.05).(3)The values of PLT,CRP and NEUT% of IM group were lower than those of non-IM group(P<0.05);the values of LYM%,LYM,LDH,AST,ALT,and EB viral load of IM group were higher than those of non-IM group(P<0.05);the values of CD3+ and CD3+CD8+ in the IM group were higher than those in the non-IM group(P < 0.05);the values of CD4+/CD8+ and CD3+CD4+ were lower than those in the non-IM group(P<0.05);the values of Ig G and Ig M in the IM group It was higher than the non-IM group(P<0.05).Conclusion: In children with Epstein-Barr virus infection in our hospital,the peak period of IM and non-IM is in infants and young children,with males predominantly.Epstein-Barr virus infection can occur throughout the year,and both IM and non-IM are more common in summer and autumn.The clinical manifestations of the IM group after EB virus infection were tonsil enlargement,tonsil white discharge,lymphadenopathy and eyelid edema more common than the non-IM group.The T lymphocyte subsets and the EBV-DNA load are conducive to the diagnosis of IM and the evaluation of the disease.