Clinical Study On The Effect Of Huatantongluo Decoction On Obesity-related Hypertension And TLR4/NF-kB Inflammatory Signaling Pathway

Objective:To explore the clinical efficacy of huatan tongluo decoctio n in the intervention of obesity-related hypertension patients,and to stu dy its effect on the TLR4/NF-k B inflammatory signaling pathway,and to eva luate the efficacy and safety of huatan tongluo decoction.Methods:A total of 70 patients with obesity-related hypertension synd rome of phlegm and blood stasis were included,all of whom met the inclus ion and exclusion criteria.The 70 cases were numbered and randomly assign ed to statistical software after random number sampling.After excluding a nd excluding the isolated cases,31 cases were divided into the experimen tal group and 30 cases were divided into the control group.30 patients in the control group were given western medicine treatment(daiwen 80 mg qd/160 mg qd),and 31 patients in the experimental group were given Chinese and western medicine treatment(based on the control group + 100 ml bid for 1bag of huayu decoction,divided into morning and evening warm treatment).B oth groups were observed for 12 weeks.Test process observation before an d after treatment in patients with diastolic and systolic blood pressure,waist circumference,body mass index,TCM syndrome integral,fasting insul in,insulin resistance index,triglyceride,cholesterol,low-density lipoprot ein cholesterol,(LDL-C),high-density lipoprotein cholesterol(HDL-C),TLR-4 protein,NF-k B p56 protein,interleukin 6 and tumor necrosis factor alpha,monocyte chemotactic factor(MCP-1)and related indicators.Results:The total effective rate of lowering blood pressure was 96.7% in the experimental group and 86.67% in the control group,The effect of lowering blood pressure in the experimental group was better than that in the control group,and the difference was statistically significant(p<0.05).The total effective rate of TCM symptom improvement in the experimenta l group was 80.65%,while that in the control group was 43.33%.The experim ental group was better than the control group in the improvement of sympt oms such as dizziness,obesity,chest distress,chest pain,headache,limb num bness and tinnitus,and the difference was statistically significant(p<0.05).Compared with before treatment,31 cases of patients in body mass index(BMT),waist circumference,triglycerides,cholesterol,low density lipopro tein cholesterol(HDL-C),fasting insulin,insulin resistance index were si gnificantly lower,the difference was statistically significant(p<0.05).c urative effect is better than that of control group,the difference was st atistically significant(p<0.05),no difference between the two groups of h igh-density lipoprotein cholesterol(HDL-C)before and after treatment(p<0.05);In the TLR4/NF-k B signaling pathway,TLR-4 protein,NF-k B p56 protein,i nterleukin-6,tumor necrosis factor-leupline,and monocyte chemokine(MCP-1)in the experimental group of 31 patients showed statistically significa nt differences compared with those before treatment(p<0.05),and the effic acy was better than that in the control group(p<0.05).Conclusion:Resolving phlegm and tongluo decoction can effectively int ervene the blood pressure of patients with phlegm and blood stasis syndro me of obesity-related hypertension,effectively reduce weight,improve lip id metabolism,and affect the TLR4/NF-k B inflammatory signaling pathway to improve insulin resistance.