| ObjectiveTo evaluate the effect and safety of catgut embedding at back-Shu acupoint in the treatment of type Ⅰ and Ⅱ myasthenia gravis(spleen-stomach deficiency),and to provide clinical ideas for acupuncture treatment of neuromuscular diseases.MethodsRandomized,parallel controlled research methods were adopted.66 qualified patients with type Ⅰ or Ⅱ MG(spleen-stomach deficiency)were randomly divided into control group and treatment group at 1:1.Participants in the control group were treated with basic drugs,while the treatment group received catgut embedding at back-Shu point in addition to the basic drug treatment.The acupoints of treatment group were Feishu(BL13),Xinshu(BL15),Ganshu(BL18),Pishu(BL20),Shenshu(BL23)on both sides.Catgut embedding therapy was given once every 2 weeks in the treatment group.All participants were scored by scale before entering the group and after one course of treatment(4 weeks),with Myasthenia Gravis Composite(MGC)scale(Primary outcomes),MG-activities of daily living(MG-ADL)and quantitative scores of TCM syndromes(Secondary outcomes)before and after the treatment.The data were entered and processed by software SPSS 26.0.P<0.05 were taken as a statistically significant standard,while P<0.01 standarded for significant statistical significance.Results1.From August 2019 to January 2020,66 patients suffered from type Ⅰand Ⅱ MG(spleen-stomach deficiency)were selected in ward and outpatient clinics of the First Affiliated Hospital of Guangzhou University of Chinese Medicine.2 cases in the treatment group was removed and 31 cases were completed.No cases were removed or excluded in the control group.In the end,64 cases were completed totally.2.Baseline comparison:There was no significant difference in age,course of disease,sex,case classification,MGC score,MG-ADL score,TCM symptom grading and quantitative score before treatment,between both groups(P>0.05).The data between the two groups were clinically comparable with statistically significant difference.3.Efficacy comparison:At the end of treatment,0 cured cases,5 markedly effective cases,26 effective cases and 0 ineffective cases in the treatment group and the total effective rate was 100%.0 cured cases,1 markedly effective case,30 effective cases and 2 ineffective cases in the control group and the total effective rate was 93.9%.The difference between two groups was statistically significant(P<0.05).4.Comparison of MGC score:The MGC score of both groups decreased after treatment.The treatment group decreased more with statistically significant difference(P<0.01).5.Comparison of MG-ADL score:The MG-ADL score in the two groups decreased after treatment.The treatment group decreased more with statistically significant difference(P<0.01).6.Comparison of quantitative scores of TCM syndromes:The quantitative scores of TCM syndromes in both groups decreased after treatment.The treatment group decreased more with statistically difference(P<0.05).7.Safety comparison:During the trial,there were no obvious adverse reactions or serious adverse events in the two groups.Conclusion1.The results suggest that both catgut embedding at back-Shu acupoint with basic drugs and only basic drugs could obtain satisfactory effect,which can improve patients’ symptoms and life quality.2.Catgut embedding at back-Shu acupoint with basic drugs achieves better effects than only basic drugs in the treatment of patients with typeⅠ and Ⅱ MG(spleen-stomach deficiency),which is favorable in safety and worthy of promotion. |
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