Discussion On 5G Support Neuronal Regulation Surgery For Drug Refractory Epilepsy And Parkinson’s Disease

Objective:To investigate the preoperative evaluation and efficacy of vagus nerve stimulation（VNS）for drug refractory epilepsy（DRE）with 5G remote control of video-electro encephalo graphy（V-EEG）;Efficacy of 5G remote controlled deep brain stimulation（DBS）in the treatment of Parkinson’s disease（PD）.Methods:A total of 14 DRE patients in the Functional Neurosurgery Department of Bengbu Third People’s Hospital from August 2019 to December 2020 were selected as the drug refractory epilepsy group and 10 PD patients as the PD group.In the drug refractory epilepsy group,VNS was performed after remote controlled V-EEG preoperative evaluation,and 5G remote controlled DBS was performed in the PD group.The stimulation parameters were adjusted according to the changes of patients’ symptoms.Mc Hugh scale and modified Engel scale were used to evaluate the frequency of seizure reduction in drug refractory epilepsy group.UPDRS Ⅱ and Ⅲscores were used to evaluate the improvement of symptoms before and after operation,and evaluate the comparison of levodopa equivalent daily dose before and after surgery.Results:1.Drug refractory epilepsy group: Mc Hugh classification:Ⅰlevel 5 cases（35.6%）,Ⅱ level 3 cases（21.6%）,Ⅲ level 3 cases（21.4%）,Ⅳ level 0（0）,Ⅴ level 3 cases（21.4%）;modified Engel classification: Ⅰ level 2 cases（14.2%）,Ⅱ level 1 case（7.1%）,Ⅲ level 5 cases（35.8%）,Ⅳ level 6 cases（42.9%）.The results suggest that VNS can effectively reduce the frequency of DRE and improve the symptoms of DRE patients.In the early stage of program control,the use of antiepileptic drugs was not adjusted,but with the emergence of VNS stimulation effect,the type and quantity of antiepileptic drugs were slowly reduced in some patients.Transient hoarseness occurred in a patient.2.Parkinson Disease: The average improvement rate of UPDRSⅡ score in the off period was（47.38 ±10.59）%.The average improvement rate of the UPDRSⅡscore in the open period was（54.43±16.21）%.The average improvement rate of the UPDRS Ⅲ score in the off period was（48.27 ± 10.10）%.And the average improvement rate of UPDRS Ⅲ score in the open period was（57.51±12.36）%.The average degradation rate of the oral LEDD in 1 year after surgery reached（41.32 ±20.71）%,and the difference was statistically significant（P<0.05）.No obvious complications were found in PD patients.Conclusion:1.Neuromodulation techniques for various types of DRE can reduce the frequency of seizures,and PD with poor drug control can also greatly reduce symptoms.2.The efficacy of 5G remote-controlled neuromodulation surgery in the treatment of DRE and PD can achieve the homogenous neuromodulation surgical treatment effect of superior hospitals.