| ObjectiveBy observing the clinical efficacy and recurrence rate of Zhichi Zuojin Decoction combined with rabeprazole in the treatment of non-erosive reflux disease(liver and stomach heat stagnation syndrome).Providing a reference and treatment idea for the clinical treatment of non-erosive gastroesophageal reflux disease(liver and stomach heat stagnation syndrome).MethodsCollect the patients diagnosed as non-erosive reflux disease(liver and stomach heat stagnation syndrome)from February 2020 to February 2021 of the Sichuan Provincial Hospital of Traditional Chinese Medicine,and randomly divided 72 patients who met the inclusion criteria into the treatment group(Zhici Zuojin Decoction combined with rabeprazole)and control group(rabeprazole),36 cases in each group,the drugs were taken orally,the course of treatment was 4 weeks,and the informed consent was signed.Before treatment and when the treatment period was 2 weeks(2w)and 4 weeks(4w),the patients’ general condition,TCM symptom scores and RDQ scores were collected and sorted.8 weeks(8w)after the end of the treatment course,a return visit was made to the cured,markedly effective,and effective patients,and the RDQ questionnaire was filled in.The SPSS 26.0 system software was used for data analysis to compare the clinical efficacy and recurrence rate between the two groups of patients.ResultsIn this study,the control group and the treatment group each excluded 1 drop-off patient,and a total of 70 patients completed the test.1.Total effective rate: When the treatment cycle was 4w,the effective rate of the treatment group(94.3%)was significantly better than that of the control group(80.5%),which with a significant difference(P<0.01).2.TCM symptom total score: When the treatment period was 2w and 4w,the total symptom score of each group was obviously improved(P<0.01),and the treatment group was better than the control group at 4w(P<0.01).3.TCM main symptom score: When the treatment cycle was 2w and 4w,and compared with 2w and 4w,each group had a significant improvement in acid reflux and heartburn(P<0.01),and the two groups had the same effect(P>0.05).4.TCM minor symptom score: When the treatment period was 2w and 4w,the improvement of the minor symptoms of the treatment group was better than that of the control group(P<0.05),there were obvious differences in the improvement of abdominal distension,full flanks fullness,upset and irritability,dry mouth and bitter mouth constipation(P<0.01);while the improvement of upset and irritability and constipation in the control group only had a significant difference in 4 weeks(P<0.05,P<0.01).There was a significant difference in the improvement of abdominal distension,dry mouth and bitter mouth at 2w and 4w(P<0.01).5.RDQ total score: When the treatment period was 2w and 4w,the total score of each group was significantly improved(P<0.01),and the improvement is equivalent(P>0.05).6.RDQ symptom scores: When the treatment period was 2w and 4w,and compared with 2w and 4w,the symptom scores of each group were significantly improved(P<0.01),and the two groups improvement on acid reflux,heartburn,and chest pain had no significant difference(P>0.05),and the improvement of reflux symptoms in the treatment group was better(P<0.05)after 4w.7.Recurrence rate: The recurrence rate of the treatment group(2.86%)was lower than that of the control group(20.59%),which with a significant difference(P<0.05).In summary,Zhichi Zuojin Decoction combined with rabeprazole is more effective than rabeprazole in treating non-erosive reflux disease(NERD)with stagnant heat of the liver and stomach.ConclusionThe application of Zhichi Zuojin Decoction combined with rabeprazole in the treatment of NERD(liver and stomach heat stagnation syndrome)is superior to single use rabeprazole in improving abdominal distension,fullness of the two flanks,upset and irritability,dry mouth and bitter mouth,and constipation,which with low recurrence rate and no obvious adverse reactions. |
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