Effects Of Metabolic Syndrome And Related Factors On Abnormal Urine Metabolism In Patients With Upper Urinary Tract Stones

Objective The aim of the study was to investigate the relationship between metabolic syndrome and its related factors and the risk of urinary metabolic abnormalities in patients with upper urinary calculus.Methods Date were retrospectively analyzed from 188 patients who with and without metabolic syndrome were hospitalized in the department of Urology,first affiliated hospital,Xin Jiang Medical University from November 2019 to July 2020.Out of 120 patient,88 patients had upper urinary tract stones with metabolic syndrome.Grouping is based on whether it is accompanied by abnormal urine metabolism,The x~2test and non-parametric test were used to analyze the prevalence and clinical characteristics of metabolic syndrome and its related factors in the two groups.Binary Logistic regression was used to analyze the risk factors of various types of abnormal urine metabolism in patients with upper urinary calculi,these risk Factors related to MS.Results(1)Compared with patients without MS,patients with upper urinary tract stones with MS are older[57.50(48.25,67.50)years and 45.50(31.00,55),Z=-5.438,P(27)0.001],the incidence of hypercalciuria was lower(25.00%vs.42.50%,P<0.05),those with hypercalciuria the incidence is lower(25.00%vs.42.50%,P<0.05).(2)After logistic regression adjustment for MS-related factors,Fasting Blood Glucose(FBG)>6.1 mmol/L increased the risk of hypomagnesuria in patients with upper urinary calculi(OR=4.998,95%CI is 1.939～12.879,P<0.05).Diabetes and hyperuricemia increase the risk of patients with upper urinary calculi with low p H urine[OR value and(95%CI)is 7.011(1.875～26.223),3.536(1.249～10.009),P<0.05],hyperuricemia reduces the risk of hypercalciuria in patients with upper urinary calculi(OR=0.25,95%CI is 0.080～0.784,P<0.05).Conclusion MS-related factors are related to the occurrence of abnormal urine metabolism in patients with upper urinary tract stones.FBG>6.1mmol/L,diabetes,and hyperuricemia may be independent risk factors for the occurrence of abnormal urine metabolism in patients with upper urinary tract stones.However,the risk of occurrence does not increase with the increase in the number of MS-related factors,and whether it is combined with MS has nothing to do with the occurrence of abnormal urine metabolism in patients with upper urinary tract stones.