Clinical Observation On The Influencing Factors Of Bone Mineral Density In 550 Patients With Type 2 Diabetes Mellitus

Objective:Through clinaical observation influencing factors of bone mineral density in diabetic patients,to clarify the pathogenesis of osteoporosis and the influencing factors of bone metabolism,in order to effectively prevent osteoporosis.Methods:In this study,550 patients with type 2 diabetes who underwent physical examination in our hospital from December 2014 to December 2015 and met the inclusion and exclusion criteria were collected as the diabetes group.At the same time,530 healthy patients of similar age and gender who received physical examination in the hospital were selected.As a control group,the physical examiner used a dual-energy X-ray bone densitometer(Norland XR-46,USA)to measure the bone mineral density of the patient.The measurement indicators include the BMD of the 2-4th lumbar vertebrae and femoral neck.The clinical data was retrospectively analyzed,and the bone density expression of the subjects under the conditions of male female ande different age,fatty liver severity,blood pressure,glycosylated hemoglobin,subcutaneous fat thickness and blood sugar were compared and analyzed,and the correlation between each index was analyzed.At the same time,multiple linear regression was used to analyze the influencing factors of bone density changes.Results:102 cases of the diabetes group had osteoporosis after bone density test,accounting for 18.5%,and 63 cases of the control group had osteoporosis after bone density test,accounting for 11.89%.The control group had osteoporosis and bone.The incidence of volume reduction was significantly lower than that of the diabetes group(P<0.05);the femoral neck BMD and lumbar spine BMD of the male subjects in the diabetes group and the control group were higher than those of the female subjects(P<0.05),and in the diabetes group The femoral neck BMD and lumbar spine BMD of male and female subjects were lower than those of subjects of different genders in the control group(P<0.05);the femoral neck BMD and lumbar BMD of subjects in the diabetes group and control group The changes continued to decrease with the increase of age(P<0.05),and the femoral neck BMD and lumbar spine BMD of the subjects in the diabetes group were lower than those of the same age in the control group(P<0.05);The changes of femoral neck BMD and lumbar spine BMD of the examinee continued to decrease with the deepening of fatty liver severity(P<0.05),and the femoral neck BMD and lumbar spine BMD of subjects with different fatty liver severity in the diabetes group were lower than those of the control group There was no significant difference in the changes of femoral neck BMD and lumbar spine BMD of subjects with different blood pressure levels in the diabetes group and the control group(P>0.05).The diabetes group The femoral neck BMD and lumbar spine BMD of subjects with different blood pressure levels were lower than those of the same blood pressure level in the control group(P<0.05);because the number of subjects with glycated hemoglobin and abnormal blood glucose in the control group was none,only The BMD expression of subjects with different glycosylated hemoglobin and blood glucose levels in the diabetes group was compared,and it was found that the subjects femoral neck BMD and lumbar spine BMD changes were continuously reduced with the increase of glycosylated hemoglobin level and blood sugar(P<0.05));The changes in femoral neck BMD and lumbar spine BMD of subjects in the diabetes group and the control group increased continuously with the deepening of subcutaneous fat thickness(P<0.05),and the femoral neck BMD of subjects with different subcutaneous fat thickness in the diabetes group The BMD of the lumbar spine and the control group were lower than those of the same subcutaneous fat thickness in the control group(P<0.05);the changes of BMD of femoral neck and lumbar spine in diabetic decreased with the prolongation of the course of disease(P<0.05);the correlation analysis showed that the BMD expression of the femoral neck was positively correlated with the thickness of subcutaneous fat,height,weight and BMI(P<0.05),And was negatively correlated with age(P<0.05),lumbar spine BMD expression was positively correlated with subcutaneous fat thickness,height,weight and BMI(P<0.05),and was negatively correlated with age,glycosylated hemoglobin and blood sugar(P<0.05);Multiple The results of linear regression analysis showed that gender,age,menopause,height and BMI were independent factors influencing the BMD value of femoral neck and lumbar spine(P<0.05).Conclusion:The incidence of osteoporosis in diabetic patients is higher than that in healthy people.Glycated hemoglobin,subcutaneous fat thickness,blood sugar,height,weight and BMI are all closely related to changes in the body’s bone density,including gender,age,menopause,height and BMI It is an independent influencing factor that affects changes in bone mineral density.Regular monitoring of bone mineral density should be strengthened in clinical practice.For patients with bone loss,osteoporosis can be prevented by controlling their own weight,and the monitoring of bone mineral density in diabetic patients should be strengthened.