Retrospective Study Of Correlation Analysis Between Hematological System Damage And Immunological Changes In Primary Sjogren’s Syndrome

Objective: To study the correlation between specific antibody and abnormal immunology index and hematological impairment in patients with p SS,and analyze the characteristics of hematological changes and serum markers in patients with p SS,so as to determine the relevant and reliable predictors in the patients with p SS.Methods: Reviewe and analyze the clinical data of 171 consecutive patients who were initially diagnosed with p SS during their hospitalization from January 2010 to February2020 at the Department of Hematology rheumatology and immunology,aiming at anti SSA / SSB / Ro-52 antibodies,Ig A / G/ M,C3 / 4,RF,and SF,and analyze the associations between hematologic damage and the above serum markers in patients with p SS.Results: 1.Among the 171 cases,65 cases(38.0%)had no hematological impairment,another 106 cases(62.0%)were combined with hematological damage,53 cases(31.0%)of leukopenia,39 cases(22.8%)of anemia,and 14 cases(8.2%)of thrombocytopenia.2.Antibody positive rate: Anti SSA,SSB and Ro-52 antibodies were positive in 72.2%,38.5%,69.8% of 171 patients,respectively.4.Comparison of each observation index:(1)Age: there was no significant difference between the two groups(P > 0.05).(2)anti-SSA/SSB /Ro-52 antibody: the positive rates of anti SSA and SSB antibodies in the blood system damage group were significantly higher than those in the non blood system damage group(P < 0.05),and the patients with anti SSA antibody positive(P < 0.05,or =4.101)were more likely to secondary leukopenia than those with anti SSB antibody positive(P < 0.05,or = 1.327),while the patients with anti SSB antibody positive were more likely to cause anemia and thrombocytopenia(P < 0.05,or = 1.327),OR=2.697;P<0.05,OR=3.026).(3)Ig A,Ig M,Ig G: there was significant difference in Ig G level among leucopenia group and anemia group(P < 0.01),but there was no significant difference in Ig A and Ig M level(P > 0.05),and there was a negative correlation between the increase of Ig G and leukocyte count,platelet count and hemoglobin(P < 0.05).(4)C3,C4:there were significant differences in C3 level among leukopenia group,anemia group and thrombocytopenia group(P < 0.01),but no difference in C4 level(P > 0.05),and the white blood cell count,hemoglobin and platelet count were positively correlated with the reduction of C3(P < 0.05).(5)SF and RF: there was no significant difference in SF and RF between the leucopenia group,anemia group and thrombocytopenia group and the non blood system affected group(P > 0.05).Conclusion: The occurrence of hematological complications in patients with p SS may be closely related to anti-SSA,SSB antibody,complement and Ig G levels.And anti SSA antibodies were more strongly associated with PSS leukopenia,and anti SSB antibodies were more strongly associated with PSS anemia and thrombocytopenia.Dynamic monitoring of blood routine,autoantibodies,complement and immunoglobulin in patients with PSS can detect the occurrence of secondary blood system damage in a certain extent,thus improving prognosis..