Expression Of Leucine Rich α2 Glycoprotein In Serum Of Patients With Rheumatoid Arthritis

Objective: We determine and compare the serum levels of leucine rich alpha-2glycoprotein(LRG)in people with rheumatoid arthritis(RA)and healthy controls,and contrast the relationship between ESR,CRP,cytokines and LRG.Objective to discuss the serological expression of LRG in RA patients and its significance in estimating in evaluating disease activity.Methods: We gather and organize the clinical data of 50 newly diagnosed RA patients and 34 healthy people and according to dsa28 score divided them into low activity group,medium activity group and high activity group.Compared the LRG levels of RA patients,control group and different activity groups,and analyze the correlation between LRG and CRP,ESR,IL-17 and other cytokines.Results: Compared with healthy controls,LRG serum level was noticeably higher in RA patients(P < 0.001).The serum LRG level of RA patients in high disease activity group was exceed that in low and middle activity groups,and the differences were statistically significant(P < 0.01);the serum LRG level was obvious correlated with CRP(γ = 0.6599;P < 0.001),ESR(γ = 0.5573;P < 0.001)and IL-17(γ = 0.6038;P < 0.001).Conclusion: What our study suggests is that the serum LRG level is higher in RA patients,and the serum LRG level is also associated with the disease activity and IL-17 level of RA,the result shown that LRG may reflect the disease activity and progression procedure of RA patients,and it may aggravate the degree of disease by influencing angiogenesis and regulating Th17 cell differentiation,and by damaging the pathogenesis of synovium and promoting inflammation.It opens up a new direction in monitoring the disease activity and treatment of RA.