Study On Thyroid Function And Related Factors Of Office-working Population In Shenyang

Objective: The study aims to research the thyroid function of office-working population in Shenyang,and analyze the related factors.Methods: The people who underwent physical examination from January 1,2014 to December 31,2020 in the First Affiliated Hospital of China Medical University were included in this study.They were adults from more than 200 offices in Shenyang.After eliminating the duplicate data and abnormal T3 and T4,a total of 2052 people were selected.The population was divided into normal thyroid function group,subclinical hypothyroidism group and subclinical hyperthyroidism group.The related factors of subclinical hypothyroidism and subclinical hyperthyroidism were analyzed by logistic regression.There was statistical significance when P <0.05.Results: The prevalence of subclinical thyroid dysfunction was 5.80%,the prevalence of subclinical hypothyroidism was 3.65%,and the prevalence of subclinical hyperthyroidism was 2.14%.The prevalence of subclinical hypothyroidism in women was significantly higher than that in men.With the increase of age,the prevalence of subclinical hypothyroidism is increasing,while the prevalence of subclinical hyperthyroidism is decreasing.The risk of subclinical hyperthyroidism in male was higher than that of women(OR=1.972,P <0.05).The prevalence of subclinical hypothyroidism in men was significantly correlated with age(OR=1.058,P <0.001).The positive of TPOAb(OR=6.086,P <0.001)or TGAb(OR=4.695,P <0.001)was the risk factor of subclinical hypothyroidism,especially in the elderly(OR=4.994,P<0.05).Diastolic pressure is an independent risk factor for subclinical hypothyroidism(OR=5.475,P <0.05),while high systolic blood pressure increases the risk of subclinical hypothyroidism(OR=2.835,P <0.05),and increases the risk of subclinical hyperthyroidism(OR=2.422,P <0.05).The increase of FT3(OR=0.463,P <0.001),FT4(OR=0.532,P <0.001)in the normal range reduced the risk of subclinical hypothyroidism.The increase of FT4 concentration could even reduce the risk of subclinical hyperthyroidism(OR=0.571,P <0.05).Conclusion: This study found that the prevalence of subclinical hypothyroidism is related to age and gender of office-working population in Shenyang.Positive thyroid autoimmune antibody is a risk factor for subclinical hypothyroidism.Elevated blood pressure is a risk factor for thyroid dysfunction.