Correlation Between Iodine-131 Uptake Rate With Thyroid Function Indicators And Thyroid Autoantibody Of Graves’ Disease In Childhood

Objective: Now, there still exists controversy about the use of radioactive 131 I in the diagnosis and treatment of Graves’ disease in childhood among domestic and overseas experts. Besides, the study on the Iodine-131 uptake rate of Graves’ disease in childhood is relatively less than expected.The purpose of this research is aimed at investigating the correlation between Iodine-131 uptake rate(3h, 6h, 24h) and the thyroid function indicators and thyroid autoantibody TSH receptor antibody(TRAb), thyroid peroxidase antibody(TPOAb), thyroglobulin antibodies(TGAb), thyroid microsomal antibody(TMAb) of Graves’ disease in childhood.Methods: The data is collected from the child patients admitting our hospital Growth and Development clinic with the initial diagnosis of Graves’ disease in June 2013 to September 2014. The total amount is 52,within where are 11 boys and 41 girls. The average age is 9.63±2.43(range from 5 to 14 years old). The disease duration range from 0.5 to 24 months, the average is 4.86±5.14 months. All patients in this study are required to test the serum FT3, FT4, T3, T4, TSH, TRAb, TPOAb, TGAb, TMAb and thyroid Iodine-131 uptake rate at 3h, 6h, 24 h. FT3, FT4, T3, T4, TSH, TPOAb are detected by using chemiluminescence, and TRAb, TGAb, TMAb are detected by using elechemiluminescence. The relationship between thyroid Iodine-131 uptake rate and FT3, T3, FT4, T4, TSH, thyroid autoantibodies TRAb, Tg Ab, TPOAb, TMAb are analysised by Spearman multiple correlation.Results: The highest thyroid Iodine-131 uptake rate at 3h, 6h and 24 h are3.85%(2/52), 26.92%(14/52) and 69.23%(36/52). Nearly 30.8% patients’ 131 I uptake rate peak moved forward. The positive rate of TRAb, TPOAb,TGAb, TMAb is 100%(52/52), 88.5%(46/52), 76.9%(40/52) and 75.0%(39/52) in the 52 cases Graves’ disease in childhood.There is no significant difference between the thyroid Iodine-131 uptake rate(3h、6h、24h) with the serum FT3, T3, FT4, T4, Thyroid stimulating hormone(TSH) and thyroid autoantibody TRAb, TPOAb, TGAb, TMAb in Graves’ disease in childhood(P > 0.01). FT4 is high-positively correlated with TRAb(r=0.729, P=0.000),while TSH is negatively correlated with TPOAb(r=-0.393, P=0.004); TPOAb is high-positively correlated with TGAb(r=0.675, P=0.000); TGAb is positively correlated with TMAb(r=0.464, P=0.001); TMAb is high-positively correlated with TPOAb(r=0.705, P=0.000).Conclusions: The Iodine-131 uptake rate increased obviously at 3h, 6h and 24 h of Graves’ disease in childhood. Nearly 30.8% patients’ 131 I uptake rate peak moved forward. The incidence of peak forward phenomenon is high.Testing the Iodine-131 uptake rat has important significance for the diagnosis and treatment of Graves’ disease in childhood. Testing the Iodine-131 uptake rat can not be replaced by thyroid function indicators( FT3,FT4, T3, T4, TSH) and thyroid autoantibody( TRAb, TPOAb, TGAb,TMAb).As a result, the combined detection of TSH and thyroid autoantibodies Tg Ab, TPOAb and TRAb has an important reference value on the clinical diagnosis and identification of Graves’ disease.