Study On The Correlation Between Celiac Disease And Autoimmune Thyroid Disease

Objective: To analyze the etiological relationship between Celiac disease(CD)and autoimmune thyroid disease,and to provide reference for the treatment of CD.Methods: In study 1: a total of 46 patients diagnosed with CD in the Gastroenterology Department of Xinjiang Uygur Autonomous Region People’s Hospital from September 1,2020 to September 1,2022 were included in the case group.During the same period,a total of 4 6 patients with abdominal pain were selected according to gender,age,a nd ethnic group 1:1 matching and were screened out after CD diagnosis.Anti-thyroid peroxidase antibody(anti-TPOAb),anti-thyroglobulin antibody(anti-TGAb),thyroid stimulating hormone(TSH),thyroid hormone(triiodothyronine(T3),tetriodothyronine(T4)and free triiodothyronine in serum of CD patients and control group were d etermined by chemiluminescence immunoassay(FT3),free tetraiodothyronine(FT4)).Study2:The relationship between CD and autoimmune thyroid diseases was investigated by computer retri eval in Pub Med,Embase,Cochrane Library,CNKI,Wanfang,and Weipu Chinese scientific journals.The retrieval time was from the establishment of the database to January 2022,and the quality evalua tion and data extraction were carried out for the included l iteratures.The meta-analysis was completed using Stata/MP17.0 software,an d the oddsratio(OR)and its 95%confidenceinterval(CI)were combined.Results: In study 1 : There were statistically significant differences in serum levels of anti-TPOAb,anti-TGAb,TSH and FT3 in patients with CD compared with control group(P < 0.05),but there were no statistically significant differences in serum levels of T4,FT3 and FT4 compared with control group(P>0.05).The detection rates of anti-TPOAb and anti-TGAb in group CD(14.70%,13.40%)were higher than those in control group(8.70%,8.70%),and the difference was statistically significant(P <0.05).The detection rate of hypothyroidism was 33.30% in the CD group and13.00% in the control group.The difference between the two groups was no statistically significant(P>0.05).In study 2:13 literatures were finally includ ed,Results suggested that CD patients had a 3.86-fold increased risk of autoimmune thyroid gland disease compared with the control group(OR=3.86,95% CI:3.06-4.87).In addition,the prevalence of hypothyroidism in patients with CD was3.81-fold higher than in the control group(OR=3.81,95% CI: 2.83-5.14),but there was no significant increase in the ris k of hyperthyroidism in patients with CD.There was no significant difference in the risk of thyroid autoimmunity between the gluten-free group and the untreated group(OR=1.09,95%CI :0.74-1.60).The associated risk of autoimmune thyroid disease was higher i n children with CD(OR=5.45,95%CI: 3.71-7.99)than in adults with celiac disease(OR=3.15,95%CI: 2.34-4.23).Conclusion: The positive rate of anti-TPOAb and anti-TGAb in CD patients is high.There may be a certain correlation between CD and autoimmune thyroid disease,which has certain clinical sig nificance for the detection of thyroid autoantibody,TSH and thyroid hormone levels in CD patients.The effect of GFD treatment on thyroid autoimmune progr ession in CD patients is still controversial and needs to be explored in longitudinal follow-up studies with larger sample sizes.