Clinical Effect Of Xian Che Fu Chao Yin Decoction With Artificial Cycle Therapy On Premature Ovarian Insufficiency Of Kideny Deficiency And Blood Stasis Type

Objectives: By observing of kidney deficiency and blood stasis type Premature ovarian insufficiency(POI)patients’ changes of Traditional Chinese Medicine(TCM)syndrome,hormone level,gynecological ultrasonography manifestation before and after treatment to explore the clinical curative effect of Xianche Fuchao Decoction integrated with artificial cycle of hormone repacement on POI and to summarize the clinical experience of treating POI with TCM and explore new ideas and methods for the clinical diagnosis and treatment of POI.Methods: Collecting 42 patients with kidney deficiency and blood stasis type POI that conformed to the inclusion criteria in First Affiliated Hospital,Heilongjiang University of Chinese medicine’s department of gynaecology from september 2018 to October 2020,and dividing into the observation group(Xianche Fuchao Decoction+ artificial cycle therapy)21 cases and 21 cases in control group(artificial cycle therapy)whereby the random number table method.One month is a treatment course,3 courses in total.Observed indicators of patients before and after treatment were recorded in detail,including the TCM syndrome scores,endocrine serum indexes(include FSH,LH,E2,T and AMH),gynecological ultrasonography manifestation(include ovarian volume,endometrial thickness and number of sinus follicles)and Safety index measurement.Results:1.Comparison of clinical efficacy: Among the entire 42 patients group included in this study,2 patients fell off(1 case in the observation group,1case in the control group).In constrast,the total effective rate of the observation group was 95%,which was significantly superior than 75% in the control group,and the discepancy was statistically significant(P<0.05).2.Statistical analysis of TCM syndrome integral: intra-group comparison demonstrated that the aggregate TCM syndrome scores of the two groups after treatment were significantly reduced than those before treatment(P<0.01);the aggregate scores of TCM symptoms in the observation group was lower than that in the control group(P<0.05).While compared with the control group,there was no significantly discrepancy among the improvement of menstrual quantity,dizziness and tinnitus,hot flashes sweating,insomnia and dreaminess,decreased sexual desire(P>0.05),the improvement of other syndromes was statistically significant compared with the control group(P<0.05).3.Analysis of serum sex hormone levels: intra-group comparison illustated that after treatment,in termes of the serum levels of FSH,LH,both the observation group and the control group were declined than that before treatment(P<0.01),meanwhile,the serum levels of E2,T,AMH were higher than those before treatment(P<0.01);Compared with the control group,the improvements in the observation group were more remarkable than the control group,and as for the serum levels of FSH,LH,E2,T,the difference was statistically significant(P<0.05).Nevertheless,there was no significant discrepancy when it comes to the AMH level(P>0.05).4.Analysis of the results of gynecological B-ultrasound examination:intra-group comparison implied that after treatment,both in the observation group and the control group,the ovarian volume,endometrial thickness and the number of sinus follicles were increased(P<0.01);furthermore,the improvements in endometrial thickness,sinus follicle number and ovarian volume in the observation group were more distinct than those in the control group,and the discrepancy were statistically significant(P<0.05).Conclusion1.Xianche Fu Chao decoction combined with artificial cycle treatment of POI has definite clinical efficacy,and can effectively adjust serum FSH,LH,E2,T,AMH level,deminish a series of perimenopausal symptoms caused by the decrease of estrogen level in patients.Additionally,in terms of improving the ovarian volume,sinus follicle number and endometrial thickness,the effect of the hybrid therapies were better than that of solely administrate artificial cycle treatment.2.In this research,Xianche Fuchao decoction integrated with artificial cycle treatment of POI showed no obvious negative and toxic side effects in clinical application.Therefore,the integration of the two therapies for POI was deemed safe and effective and deserve further clinical research and promotion.