| BackgroundAcute pancreatitis(AP)is one of the more common diseases in clinical medical work.It is the auto-inflammation and cell damage process of pancreatic tissue.To a certain extent,it can spread to nearby tissues and organs and other organs.When the disease is mild,it can heal itself,and when the disease is severe,it can produce severe clinical symptoms and even lead to the death of the patient.Since the 1980 s,somatostatin has been used clinically,and its therapeutic effect is not as ideal as expected by clinicians.Until now,there are still few studies on the time of administration of somatostatin.ObjectiveUnderstand the difference of somatostatin administration time and its curative effect in acute pancreatitis.Provide reference and reference for clinical treatment of acute pancreatitis.MethodsThe general data of 113 mild acute pancreatitis(MAP)and 40 severe acute pancreatitis(SAP)patients treated by Shangqiu First People’s Hospital from July 2019 to December 2019 were analyzed by consulting clinical cases.According to the time point from the onset of the disease to whether the administration of somatostatin is greater than24 hours,the included clinical cases are divided into 4 groups.Group A is MAP patients and the application of somatostatin is given within 24 hours of onset.Group B is for MAP patients and is given somatostatin application 24 hours after onset,group C is for SAP patients and is given somatostatin application within 24 hours after onset,and group D is for SAP patients and is given somatostatin application 24 hours after onset.The 4groups of patients used the same treatment drugs and the same nursing measures to compare the improvement of the general symptoms of the 4 groups of patients and the improvement of laboratory inspection indicators.The general condition data mainly include the disappearance of abdominal pain and bloating,the number of days in hospital,and the complications Circumstances,the laboratory inspection items mainly include the number of white blood cells,the value of C-reactive protein,blood calcium level,the situation of procalcitonin,as well as changes in the distribution of red blood cells and fluctuations in average platelet volume.Results1.Summarize the general clinical information of acute pancreatitis collected this time.The specific case data are as follows: The total number of patients included in this retrospective analysis is 153,of which 107 are males,accounting for 69.9% of the total patients,and female patients 46 people,accounting for 30.1% of the overall patient ratio.2.Analyze the gender composition of the patients from each group of the included cases.The total number of patients in group A is 83,including 66 male patients and 17 female patients;the total number of patients in group B is 30,including 22 male patients and 8 female patients;group C The total number of patients is 19,including 7 male patients and 12 female patients;there are 21 patients in group D,12 male patients and 9female patients.3.Analyze the age of the patients from each group of the included cases.The age composition of patients in group A is 21-72 years old,and the average age ± standard deviation is(38.80±12.07).The age composition of patients in group B is 15-81 years old,and the age is(46.93±11.68),the age structure of the patients in group C is 28-83 years old,the age is(48.68±16.89),the patients in group D are 23-69 years old,the age is(45.05±13.85)group A and group B exist in age The difference in data(P<0.05),there is no difference between group C and D in terms of age data(P>0.05).4.Comparison of general medical condition data The number of days for patients in group A to disappear from abdominal pain and bloating was significantly less than that of patients in group B.The data was compared and calculated,and p was less than 0.05;the number of days of hospitalization of patients in group A was less than that of patients in group B,and the data was compared and calculated(P<0.05);A The complication rate of patients in group B was basically the same as that of patients in group B,during which data were compared and calculated(P>0.05);the number of days for patients in group C to disappear from abdominal pain and bloating was less than that of patients in group D,and the data were compared and calculated(P<0.05);days of hospitalization in group C patients For patients smaller than group D,the data were compared and calculated(P<0.05);the complications of group C patients were basically the same as those of group D,and the data were compared and calculated(P>0.05).5.Comparison of laboratory inspection items after treatment,the red blood cell distribution width,blood calcium level,C-reactive protein value and procalcitonin measurement values of group A patients were better than those of group B patients after treatment.The data were compared and calculated(P<0.05);the white blood cell count and average platelet volume after treatment in group A were not significantly different from those in group B after treatment,and the data were compared and calculated(P>0.05);the red blood cell distribution width and C reaction of group C patients after treatment The protein value was better than that of the patients in group B after taking the medicine.The data was compared and calculated(P<0.05);the average platelet volume,the number of white blood cells and the level of procalcitonin after clinical intervention in group C patients were not different from those in group D after clinical intervention.For comparison calculation(P>0.05).Conclusions1.Somatostatin treatment within 24 hours during the onset of acute pancreatitis can effectively reduce the number of days of abdominal pain and bloating,and significantly shorten the average length of hospital stay.2.Giving somatostatin therapy within 24 hours during the onset of acute pancreatitis can significantly reduce the C-reactive protein and red blood cell distribution width indicators,which can promote the improvement of AP treatment regimens and shorten the course of the disease. |
PDF Full Text Request