Relationship Between Platelet Distribution Width,Neutrophil-Lymphocyte Ratio And Knee Osteoarthritis

Objective:To clarify the relationship between platelet distribution width,neutrophil to lymphocyte ratio(NLR)and radiological severity(K-L grade)of knee osteoarthritis.The relationship between platelet distribution width,neutrophil to lymphocyte ratio(NLR)and Womac score in patients with knee osteoarthritis was determined.Finally,the relationship between platelet distribution width,neutrophil-lymphocyte ratio and knee osteoarthritis was clarified.Methods:Patients with knee osteoarthritis who met the study criteria were included in the study and their age,gender and body mass index(BMI)were collected.Neutrophil count,lymphocyte count,platelet count,platelet distribution width(PDW),platelet distribution volume(MPV),and c-reactive protein were extracted from the blood routine of the patients.Patients were asked to fill in Womac scoring scale.Womac pain score,Womac stiffness score and Womac function score were recorded.X-ray examination was performed on the patients(full-length weight-bearing position of both lower limbs and positive and lateral position of knee joint)to determine the K-L grade of knee osteoarthritis.The patients were divided into two groups: K-L(grade 1-3)knee osteoarthritis(mild to moderate)and K-L(grade 4)knee osteoarthritis(severe).SPSS 25.0 software was used to analyze the relevant data.Graphpad Prism5 was used to edit the data histogram to visually display the difference of corresponding serological markers.The measurement data of serological markers were expressed as(mean ± standard deviation).General data such as gender were analyzed by chi-square test or one-way analysis of variance.The independent sample T test was performed for the correlation between serological markers and the imaging severity of the patients.Pearson correlation test was carried out for the relationship between serological markers and Womac scoring scale.In all statistical analyses,we considered P<0.05 as statistically significant.If there is statistical significance,the ROC curve(receiver operating characteristic curve)of the corresponding serological markers was studied.Results:A total of 211 patients were included in the study,including 100 K-L(1-3)patients and 111 K-L4 patients.There was no significant difference in gender ratio,age,and BMI between the two groups(P> 0.05).There is comparability.We performed an independent sample T test on the relationship between related inflammatory serological indicators and K-L grade of knee osteoarthritis,and concluded that the neutrophil-lymphocyte ratio and the radiological severity of knee osteoarthritis(KL classification)was statistically significant,while there was no statistical significance between PDW and the radiological severity of knee osteoarthritis(KL classification).We performed a ROC curve study on the relationship between the neutrophil-lymphocyte ratio(NLR)and the radiological severity(K-L classification)of knee osteoarthritis,and calculated the optimal cut-off value: NLR = 1.74,That is,NLR≥1.74 indicates the probability of severe(grade 4)radiological KOA,while NLR < 1.74 indicates the probability of mild to moderate(grade 1-3)radiological KOA,and the sensitivity of the NLR to the diagnosis of KOA radiological severity is 63% and the specificity is 77%.We performed a Pearson analysis on the relationship between related inflammatory serological indicators and the Womac score scale,and concluded that the neutrophil-lymphocyte ratio(NLR)was positively correlated with the Womac pain score and the Womac total score.The platelet distribution width(PDW)was positively correlated with the Womac stiffness score.Conclusion:Neutrophil to lymphocyte ratio(NLR)and platelet distribution width(PDW)may be involved in the occurrence and development of knee osteoarthritis,and neutrophilto lymphocyte ratio can be used as inflammatory biomarkers for radiological severity(K-L grade)of knee osteoarthritis.NLR≥1.74 indicates the probability of severe(grade 4)radiological KOA,while NLR < 1.74 indicates the probability of mild to moderate(grade 1-3)radiological KOA,and the sensitivity of NLR to the diagnosis of KOA radiological severity is 63% and the specificity is 77%.The neutrophil-lymphocyte ratio(NLR)was positively correlated with the Womac pain score and total Womac score of knee osteoarthritis patients,and the plateletdistribution width(PDW)was positively correlated with the Womac stiffness score of knee osteoarthritis patients.