Correlation Between Osteoporosis Patients And Chemokines In Middle-aged And Elderly People In Xinjiang

Objective:To investigate the correlation between osteoporosis and chemokine levels in middle-aged and elderly people in Xinjiang,and whether there are differences in chemokine levels between different genders and ethnic groups,thus providing a guiding direction for early diagnosis of osteoporosis and prevention.Methods:A total of 217 patients were enrolled in the cadre ward of the First Affiliated Hospital of Xinjiang Medical University from 2016.9-2019.2.According to the diagnosis and exclusion of osteoporosis,100 patients in the osteoporosis group and 117 healthy controls were selected.The general data and peripheral venous blood samples were collected,and serum chemokine levels were determined by enzyme-linked immunosorbent assay.The age,sex,ethnicity,body weight,body mass index(BMI),serum chemokine level,lumbar vertebrae bone density L1-4,left hip bone mineral density and related biochemical indicators were analyzed and compared.Results:The levels of chemokines in the osteoporosis group were higher than those in the control group(P<0.05),and the serum chemokine levels in the elderly patients with osteoporosis were negatively correlated with bone mineral density(r=-0.689,r =-0.316,P<0.01).There were no significant differences in the levels of chemokines between the two groups(P>0.05).body weight,BMI,LDL,OC,chemerin levels,lumbar spine BMD L1-4,left hip bone mineral density,25(OH)D The difference was statistically different(P<0.05).Conclution:Chemokine levels are correlated and negatively correlated in patients with osteoporosis(OP)in the middle-aged and elderly population.Gender and ethnic factors There was no significant difference in serum chemokine levels in middle-aged and elderly patients with osteoporosis.