| Objective To investigate the prevalence of hyperhomocysteinemia(HHcy)in general physical examination population,to analyze the effects of demographic characteristics,life behavior factors and eating habits on serum homocysteine(Hcy)in general physical examination population,to provide theoretical basis for the prevention and control of HHcy and clinical intervention treatment,and to analyze the influence of serum Hcy and its influencing factors on hyperuricemia(HUA),so as to provide a new health management approach for the prevention and treatment of HUA.Methods The routine physical examination personnel were selected from November 2019 to August 2020 in the health management center of The Second Affiliated Hospital of Dalian Medical University,and the adults who came for physical examination were investigated by questionnaire,physical measurement and laboratory examination by the method of simple random sampling.The relationships between social demographic information(age,sex,nationality,BMI),life behavior factors(smoking,drinking,nature of work),eating habits(cereal intake,meat intake,fresh vegetables and fruits intake)and HHcy were analyzed.The above factors were analyzed by univariate analysis,and the significant indexes in the results of univariate analysis were included in multivariate analysis.To understand the influencing factors of HHcy and analyze the prevalence of HHcy-related diseases such as hypertension,coronary heart disease,stroke and dyslipidemia in HHcy group and non-HHcy group.Serum Hcy was divided into four levels according to quartile method.Logistic regression model was used to analyze the relationship between serum Hcy and HUA.The structural equation model(SEM)was used to analyze the action direction and magnitude of serum Hcy and its influencing factors on HUA.Results A total of 3750 subjects were included in this study,including 2584 males and 1166 females,ranging in age from 26 to 75 years old,with an average age of 53.68 ±7.91 years.(1)Univariate analysis showed that there were significant differences in sex,age,BMI,smoking,drinking,cereal intake,meat intake and fresh fruit and vegetable intake between HHcy group and non-HHcy group.However,there was no significant difference in the nature of nationality and work between the two groups.(2)The results of multivariate Logistic regression analysis: the factors with statistical differences in the results of univariate analysis were analyzed.The results showed that male(male vs female,OR=4.251),age(each increase of 1 year,OR=1.016)and smoking(smoking vs non-smoking,OR=1.365)increased the risk of HHcy.However,meat intake(≤ 1 / day,2-3 / day,≥ 4 / day vs basically did not eat / day)(OR=0.591,0.548,0.448)and fresh fruits and vegetables intake(≤ 4 /day,5-9 / day,≥ 10 / day vs basically did not eat / day)(OR=0.538,0.454,0.409)decreased the risk of HHcy.There was no significant correlation between BMI,alcohol consumption,cereal intake and HHcy.(3)In this study population,hypertension and dyslipidemia were correlated with HHcy,while coronary heart disease and stroke were not significantly associated with HHcy.(4)Relationship between serum Hcy and HUA: univariate results showed that serum Hcy level was positively correlated with the risk of HUA,and after adjusting age and sex,the risk of HUA at Q3 and Q4 levels of serum Hcy was 1.636 and 1.569 times higher than that of Q1 level,respectively.After adjusting the intake of BMI,smoking,drinking,meat,cereal and fresh fruits and vegetables,the risk of developing HUA at the levels of Q3 and Q4 of serum Hcy was 1.684 and 1.639 times higher than that of Q1,respectively.(5)The results of structural equation model show that Hcy has a positive effect on HUA,and the standardized path coefficient is 0.010.The standardized path coefficients of sex,age,smoking,meat intake and Hcy were 0.312,0.021,0.086and-0.081,respectively.Sex,age,smoking and meat intake could also directly affect the standardized path coefficient of HUA,(0.579,-0.033,0.002,0.044).Conclusion In order to prevent HHcy,the general population should be aware of the influence of age and gender on HHcy,especially the elderly male population,should pay attention to maintaining a healthy lifestyle in diet and life,actively quit smoking and appropriately increase the intake of fresh vegetables,fruits and meat.Age,sex,smoking and meat intake can affect HUA through serum Hcy,and serum Hcy has a certain mediating effect in the pathogenesis of HUA.Therefore,effective prevention and control of HHcy may provide a new health management way for the prevention and treatment of HUA. |
PDF Full Text Request