A Randomized Controlled Clinical Study Of Microplasma Combined With Compound Betamethasone Injection In The Treatment Of Hypertrophic Scar

BACKGROUND: Hypertrophic scars(HTS)are abnormal fibrous reactions following trauma,inflammation,surgery,or burns.It is more common in the age group of 10 – 30 years.Areas with the highest skin tension are often affected by scar hyperplasia,such as the upper back,shoulders,anterior chest,and upper arms.Patients experience pain,itching,limited mobility,and psychological problems.When the hypertrophic scar extends beyond the original wound site,the duration is called keloid,which rarely disappears without treatment and tends to recur after resection.Hypertrophic scars and keloids are a challenge for the treating physician because of the weak therapeutic response,recurrence after treatment,and side effects associated with the treatment paradigm.None of the currently available scar treatments guarantees scar reduction or improvement in functional and cosmetic conditions.At present,there are many methods to treat hypertrophic scar and keloid,and their treatment methods tend to be diversified and combined treatment,because the variables will affect their development and regression(such as the location of scar,the age of patient and the type of scar,the genetic predisposition of patient,etc.),which often require the combination of various treatment methods to achieve better therapeutic effect.Objective: In this study,we sought to evaluate and compare the effective rate of Feiton microplasma combined with intra-scar injection of compound betamethasone in the treatment of hypertrophic scars versus intra-scar injection of compound betamethasone alone in the treatment of hypertrophic scars in Israel.Methods: The patients with hypertrophic scar were divided into two groups of 25 patients each,and the patients received a total of four treatments with an interval of 28 days between each treatment.The combined group was a combination of microplasma and intra-scar injection of compound betamethasone.The hormone group received only intra-scar injection of compound betamethasone.Pre-treatment measurements and photographs were taken for each treatment.Two unbiased qualified plastic surgeons independently evaluated the photographs using the Vancouver Scar Assessment Scale(VSS).Statistical analysis was performed using statistical software.The color,vascularity,softness and thickness of hypertrophic scar and the improvement of pain and itching symptoms were compared between the two groups.Results: According to the Vancouver Scar Assessment Scale score,the combined hormone group had a more significant effect on reducing the color and vascularity of the scar,with statistical significance.However,although there was no statistically significant effect on the thickness and softness of the scar,the mean values of the combined group were less than those of the hormone group,so there was clinical significance in the softness and thickness of the treatment of hypertrophic scar in the combined group.Conclucion: In the treatment of hypertrophic scars,the efficacy of Israel Fayton microplasma combined with intra-scar injection of compound by dexamethasone was better than that of intra-scar injection of compound by dexamethasone.