The Clinical Characteristics Of Fat Cotent And Fibrosis Of Liver In Various Statuses Of Metabolise

Objective: The main purpose of this study is to explore the characteristics of clinical biochemical indicators of different metabolic statuses,detect the relationship and interaction between different metabolic levels and liver fat content and the degree of liver fibrosis,and provide new basis for clinical intervention and treatment.Methods: A total of 550 subjects were selected according to the exclusion criteria.Collecting the data of gender,age,height,weight,waist circumference and calculate the body mass index.After fasting for8 hours,we collected venous blood to detect serum Alanine transferase(ALT),Aspartate aminotransferase(AST),γ-glutamyl transferase(GGT),Uric-acid,total bolirubin(TB),phosphatase(ALP),triglyceride(TG),total cholesterol(TC),lipoprotein(LDL),fasting plasma glucose(FPG),etc.All subjects were conducted Fibro Touch examination.Results:1.The incidence rate of abdominal girth,BMI,SBP,FPG,2hPG,HbA1c,TG,HDL,GGT,ALT and serum uric acid in patients with metabolic syndrome were significantly higher than those in normal metabolism group.HDL was significantly lower than normal group,and CAP and LSM also increased significantly in metabolic syndrome group.2.With the aggravation of abnormal glucose metabolism,abdominal girth,BMI,SBP,FPG,2hPG,HbA1 c,TG,homocysteine,GGT,serum uric acid,Cystatin C,CAP value and LSM value gradually increased.3.BMI,2hPG,TG and abdominal girth were independent risk factors of increasing of CAP(p<0.05),ALT and SBP were independent risk factors of increasing of LSM(p< 0.05).4.In the non-obese population,CAP and LSM values were significantly higher in the metabolic syndrome population than in the non metabolic syndrome population,and 2hPG,Lipoprotein a,HDL,GGT may be the risk factors for the increase of CAP and LSM values.Conclusion:1.Liver steatosis and fibrosis are the result of many metabolic factors.With the increase of metabolic disorder components and severity of metabolic disorder,the degree of liver fatty content and fibrosis gradually increased.2.Obesity,glucose and metabolism disorder are independent risk factors for fatty content change of liver.3.The degree of hepatic fibrosis associated with fatty liver gradually increased with the aggravation of liver cell damage and the increase of systolic blood pressure.4.In non-obese population,metabolism status is the main factor that affects liver fat content and liver fibrosis.