Clinic Analysis Of The Relationship Between Type 2 Diabetes Patients With Nonalcoholic Fatty Liver Disease And The Metabolic Syndrome

Objective: To analyze the clinical characteristics of type 2 diabetic patients with nonalcoholic fatty liver disease (NAFLD), explored the relationship between type 2 diabetes mellitus with NAFLD and Metabolic Syndrome and its components.Methods: 160 cases of type 2 diabetes patients were selected. It was divided into type 2 diabetes mellitus with non-alcoholic fatty liver disease group (NAFLD group) (n=84) and without NAFLD group (control group) (n=76) according to the B-mode Ultrasound. Weight , blood pressure , fasting blood glucose , glycosylated hemoglobin,serum uric acid,total cholesterol,triglyceride, high density lipoprotein cholesterol , low-density lipoprotein cholesterol , alanine aminotransferase , aspartate aminotransferase levels were Measured and comparatively analyzed. B-mode ultrasonic examination was performed to determine the liver fat content and participants were divided into the following three groups based on their liver fat content: mild fatty degeneration group,moderate fatty degeneration group,severe fatty degeneration group. The general situation and the biochemical indicators were compared within each fatty liver group. Finally the prevalence of metabolic syndrome and metabolic syndrome associated component were compared between NAFLD group and without NAFLD group.Results:â‘ There is no significant difference in age,gender,and duration of type 2 diabetes between NAFLD group and the control group (p>0.05);BMI,TG,ALT,LDL-C,UA were significantly higher (p <0.01),while HDL-C significantly lower than the control group,The difference was statistical significance (p <0.05).â‘¡Compared within NAFLD group,BMI,TG,ALT,UA increase and HDL-C decreased corresponding with the serve of the fatty liver;there was a significant difference (p <0.05)â‘¢The proportion of the metabolic syndrome and associated component in the NAFLD group were significantly higher than control group. The proportion of metabolic syndrome,obesity ,hypertension, hypertriglyceridemia between group were respectively 61.90%, 38.1%, 47.61 %, 50.0% and42.10%,19.73%,31.57%,31.57%, there was a significant difference (P <0. 05);The proportion of low HDL-C hyperlipidemia was high than the control group,but there was no significant difference.Conclusions: There is a high prevalence of NAFLD in patients with type 2 diabetes. NAFLD was always accompany with high blood pressure, obesity, dyslipidemia which was characteristic of insulin resistance as the central component of the metabolic syndrome. It was more obviously when fatty liver content increase. It is of great significance for the identification of type 2 diabetes with or without NAFLD because the appearance of it maybe an indicate emergence of the risk factor of cardiovascular disease.