Evaluation Of Clinical Efficacy Of Qidan Fugan Granules In Treating RRTI Qi Deficiency And Blood Stasis Syndrome And Its Effect On Blood Coagulation Function

Objective:The objective of this study is to discuss the correlation of Qi-deficiency-blood-stasis syndrome and coagulation function.The coagulation function including blood platelet count(PLT),mean platelet volume(MPV),prothrombin time(PT),activated partial prothrombin time(APTT),fibrinogen(FIB)and d-dimer(D-D).Final is to investigate the effective of qidanfugan formula granule(QDFGKL)on RRTI Qi-deficiency-blood-stasis syndrome.We attempt to expound the Qi-deficiency-blood-stasis syndrome in the theory of traditional Chinese medicine by means of modern test methods,and to explore the mechanism of action of QDFGKL in modern pharmacology.Methods:31 children,who were admitted to Dongzhimen hospital during December 2018 to August 2019,diagnosed RRTI Qi-deficiency-and-blood-stasis syndrome were included in the treatment group.Due to voluntary withdrawal and shedding,a total of 30 cases were eventually obtained.10 healthy children,from the same hospital and during the same time,were included in the control group.Treatment group oral QDFGKL for 2 months,and regular return visit every 2 weeks.After taken QDFGKL,the treatment group had to record traditional Chinese medicine(TCM)syndrome integral table in the 0,2,4,6,8 weeks and the follow-up after 6 months,record RRTI disease classification table in the 0,8 weeks and the follow-up after 6 months,record the last 2 months duration of every respiratory infection symptoms in the 0,8 weeks and the follow-up after 6 months,collected venous blood for measurement test index in the 0,8 weeks.In the control group of healthy children,no drug intervention was given,and only venous blood measurement indicators were collected on the day of enrollment.We have analyzed the effective rate of QDFGKL in the treatment of RRTI Qi-deficiency-and-blood-stasis syndrome,the remission efficiency of TCM syndrome score,the difference of coagulation function between children with RRTI and healthy children.SPSS 22.0 software was used for statistical analysis.T-test was used for measurement data of normal distribution.One-way analysis of variance was used for multi-group data.Nonparametric test was used for measurement data of non-normal distribution.The rank data is tested by the rank sum.Results:The effective rate of remission was 76.67%.The total effective rate of TCM syndrome score was 83.33%.With the increase of the medication course,the scores of TCM syndrome of Qi-deficiency and Blood-stasis were lower than those before treatment and gradually decreased(P<0.01).After treatment,symptoms duration of runny nose,cough,fever was significantly shortened(P<0.01).Symptoms duration of antiadoncus and moist crackles was shortened(P<0.05).When follow-up after 6 months,symptoms duration of runny nose,cough,fever,antiadoncus was significantly shortened(P<0.01).When follow-up after 6 months,symptoms duration of moist crackles was shortened(P<0.05).This proved that QDFGKL is effective in treating RRTI Qi-deficiency-blood-stasis syndrome.It can improve the symptoms of infection and the children’s quality of life.Secondly,it was confirmed that the children diagnoses RRTI Qi-deficiency-blood-stasis syndrome had coagulant function abnormality,which was manifested in significantly increased PLT(P<0.01),increased APTT(P<0.05),significantly decreased MPV(P<0.01),and decreased PT(P<0.05).The FIB and D-D of RRTI children were no difference with healthy children.Treatment with QDFGKL can improve children’s coagulation disorders,mainly by reducing APTT,increasing MPV and PT.The results shows that coagulation dysfunction may be one of the pathogenesis of RRTI Qi-deficiency-blood-stasis syndrome.QDFGKL can improve the coagulation function to achieve the purpose of treating RRTI.Conclusion and significance:Based on the research progress of TCM and modern laboratory,this study aims to find the laboratory evidence for Qi-deficiency-blood-stasis syndrome through modern research methods.This results can also be used to explore the pathogenesis of RRTI Qi-deficiency-blood-stasis syndrome.This results have proved that coagulant function abnormality may be one of the pathogenesis of RRTI Qi-deficiency-blood-stasis syndrome,and QDFGKL can improve the coagulation function to achieve the purpose of treating RRTI.It can provide more abundant and effective treatment methods for RRTI children.