Explore The Medication Research Of Professor Peng Yu's Treatment Of Children's Cough Based On Data Mining Technology

Objective:conclude and analyze Pf.Peng Yu’s regularity of drug using and academic thoughts on infantile cough by utilizing modern date mining technologies and methods,in order to provide new ideas for TCM’s prevention and treatment on infantile cough.Method:Over 2000 firsthand case history of outpatient service from Pf.Peng Yu are collected,among which 511 firsthand cases treating infantile cough are selected,bases on "CACMS The Inheritance of Traditional Chinese Medicine Auxiliary System V2.5" to set up database,and by the application of frequency analysis method we analyze the onset age of infantile cough.sex distribution and the frequency of drugs commonly used in the treatment of infantile cough by Pf.Peng Yu the common syndrome differentiation as well as the kernel drugs for each type of syndrome;through the association rules we analyze the type of syndrome_syndrome、medicine combination.the type of syndrome-medicine.the corresponding compatibility relations among drugs.New types of combined prescription are evolved from complex system through entropy clustering algorithm.In order to summarize Pf.Peng Yu ’s law on the treatment of children’s cough and the practice of condensing her experience.Result:①the age of onset among infants and young children was predominated by 1 to 4 years-old,accounting for 72.21%(369 cases)in 511 cases,which is consistent with what was reported in the textbooks and literatures;1(97/26.3%)and 3 years-old(116/31.4%)were the high-risk age among the child patients at age of 1 to 4 years-old,which should be stressed in clinical prevention;males than females.②infantile cough distribution:the syndrome of phlegm-heat obstructing lung ranked the first;followed in a descending order by syndrome of cold-heat complication(including the phlegm and accumulated stagnation),syndrome of phlegm-damp obstructing lung,syndrome of wind-heat affecting lung and syndrome of qi deficiency of lung and spleen.③ the medicine property is largely based on warmness,coldness and flatness,emphasizing the effect of warming and treating the lung through spleen;the medicine taste is largely based on bitterness,spiciness and sweetness,emphasizing the effect of dispersion and dispersing the qi movement;the medicines are largely tropism to lung,spleen and stomach channel.)the core medicines treating the infantile cough are:scutellaria,scorched hawthorn fruit,rhizome Pinellinae praeparata,radix stemonae,radix saposhnikoviae,platycodon grandiflorum,dandelion,almond,immature bitter orange and so on.⑤ Common drug combinations are Radix scutellariae,radix stemonae,windproof,focal method of hawthorn,almonds,pinellia tuber.⑥The new drug combinations are immature bitter orange-semen raphani-areca-Fructus aurantii and fried aster;Purple Perilla leaf-SSP-radix bupleuri-perrin;lumbricus-fructus schisandrae-grilled ephedra asarum-Perilla-asarum;Poria cocos-scutellaria-codonopsis radix stemonae-semen coicis;Poria cocos-method of pinellia tuber-dandelion-semen coicis-shoot dry-cortex dictamni;Mulberry leaf-snakegourd fruit skin-mint-trichosanthes son-it-unibract fritillary bulb.⑦the frequency of use of common medicines for each syndrome in descending order is:phlegm-heat obstructing lung uses radix scutellariae,fructus,radix stemonae,acid-insoluble ash and coke hawthorn;phlegm dampness in lungs uses method of pinellia,poria cocos,radix scutellariae,radix platycodi,coke hawthorn;simultaneous occurrence of cold and heat uses radix scutellariae,windproof,mulberry leaf,coke hawthorn.Among them,one with phlegm uses Rhizoma Pinelliae,Fritillaria thunbergii and almond;one with retention uses dried tangerine or orange peel,orange,Rhizoma Pinelliae;one with hypofunction of spleen and lung uses Poria cocos,pinellia,dried tangerine or orange peel,windproof,astragalus membranaceus;one with Wind-heat Affecting Lung uses Radix scutellariae,windproof,dandelion,mulberry leaf,coke hawthorn.Conclusion:1.Endogenous cough with phlegm-heat syndrome refers to the most common disease of infantile cough,which lays the first place.Then syndrome of intermingled heat and cold is followed.Pure cough due to wind-cold evil is less.All above are closely related with pure-yang constitution of children,feeling cold and being easy for heating up,asthenic susceptibility of spleen and food being easy for stagnation and hard for digestion;2.Treating infantile cough should well take use of gentle and acrid medicine;pay attention to warming and resolving phlegm,releasing and down-bearing the lung by acrid medicine;focus on resolving phlegm to reflecting the mentor academic thought of "treating lung from the spleen";3.Make good use of products strengthening the spleen and regulating qi,so as to regulating and smoothening the lung and the spleen,then the phlegm source gets broken.The mentor academic thought of "firstly regulating the spleen" and always "taking care of the spleen and the stomach,is presented;4.Core medicine and new medicine preparation mainly focus on functions of acrid medicine for warming,releasing and down-bearing the lung,resolving phlegm and drying dampness,and relieving asthma,and auxiliarily on the function of bitter medicine for removing cold and clearing heat,which fully shows the method of mentor of "warming phlegm" and "regulating the spleen" in treating infantile cough.The method resolves lingering phlegm from the root.Phlegm is deleted then cough is cured,which rightly meets the clinical experience of mentor for treating infantile cough by applying "curing the lung from the spleen",or"activating the spleen to releasing the lung",or "simultaneously treating the lung and the spleen".The method further lays the theoretical foundation for mentor to condense the experience of treating pediatric cough and develop the new medicine.