Medication Rule Mining Of Ming And Qing Dynasties In Treating Cough In Children Based On Data Of Chinese Medical Dictionary

Objective: Based on IBM SPSS Modeler 18 software,the prescription used by doctors in the Ming and Qing dynasties to treat children’s cough was taken as the starting point to explore the rule of its clinical medication,providing clinical basis and reference for modern Chinese medicine to treat children’s cough.Methods: The original data of prescriptions that met the requirements in the Chinese Medical Code were input into IBM SPSS Modeler 18 software in a standardized format,which was used for association rule analysis and cluster analysis,and then the statistical results were analyzed and discussed with the theory of traditional Chinese medicine.Results: 1.Drug use: In this study,233 prescriptions were included,involving 91 traditional Chinese medicines.Among them,in the treatment of children’s cough in the Ming and Qing dynasties,the frequency of medication ≥10 times were licorice,almond,Tangerine peel,Perilla leaf,pinellia platycodontia,Radix platycodontia,coltwinterflower,trichosanthes,Poria codontia,mulberry bark,ephedra,ginseng,Sichuan bulbus,ginger,ophiopogon ophiopogon,prehu,gypsum,schizonepeta,parsnax,cinnamon and schisandra.The distribution of the four qi was mainly warm drugs,followed by normal drugs.The five tastes tend to be mild,bitter and sweet.Return to the main lung meridian,spleen meridian,stomach meridian.The top three efficacy categories were phlegm relieving cough(42.49%),deficiency supplementing(18.65%)and surface relieving(16.28%).2.Association rule analysis: Association rule analysis was carried out for drugs with high frequency of association rules ≥ 10 times,and the minimum support was set as 3%,the minimum confidence was 30%,and the maximum previous item was 5.Four combinations of drugs were obtained:Perilla leaf-bitter almond,platycodon-bitter almond,tangerine peel-bitter almond,pinellia pinellia-tangerine peel.3.Cluster analysis: After cluster analysis of high-frequency drugs with frequency ≥ 10,three clusters were obtained,which were grouped as follows: Cluster 1: almond,tangerine peel,Perilla leaf,pinellia platycodon,aster,coltwinter flower,Trichosanthes,poria cocos,mulberry white bark,ephedra,ginseng,Sichuana flos,ginger,ophiopogon ophiopogon,cinnamon;Cluster 2: Prehu,gypsum,schizonepeta;Cluster 3: Schisandra and parsnip.From the three clusters,it can be seen that the treatment of children’s cough is mainly cough relieving,wind relieving and cough relieving,spleen strengthening and dehumidification drugs.Conclusion(s): Doctors in the Ming and Qing dynasties treated children with cough,attaching importance to the lungs,taking into account the spleen and stomach;Cough making good use of phlegm,lung,spleen,wind-removing traditional Chinese medicine,specimen consideration.Zhisuo powder,Xingsu powder,Erchen decoction and so on.