Clinical Study On Fuzheng Tongluo Recipe In Treating Idiopathic Pulmonary Interstitial Fibrosis And Lung Kidney Qi Deficiency Syndrome

Objective:To evaluate the efficacy of Fuzheng Tongluo Recipe in the treatment of lungandkidny Qideficiencyof idiopathic pulmonary fibrosis.Methods:According to the principle of randomized,double-blind,placebo,and parallel control,68 patients with idiopathic pulmonary fibrosis,pulmonary qi-deficiency syndrome,and non-acute aggravation were included.The treatment group was treated with non-drug therapy and Fuzheng Tongluo Granule.Treatment,control group Western medicine non-drug treatment plus Chinese medicine placebo,observation record for 16 weeks.Results:There were no significant differences in the main indicators between the two groups before treatment.After treatment,the total effective rate of the treatment group was 76.67%,and the total effective rate of the control group was 38.71%,with statistically significant difference(P<0.000).The main symptom score:cough symptom score,the treatment group and the control group were statistically different(P<0.05),there was no statistical difference between the groups(P>0.05);cough symptom score,group There was no significant difference between the two groups(P>0.05);the wheezing symptom scores were statistically poor(P<0.05),and there was no statistical difference between the groups(P>0.05).There was no significant difference in the treatment group(P>0.05),there was statistical difference in the control group(P<0.05),and the wheezing symptom score in the control group was higher than before;There was no statistical difference(P>0.05).There was no significant difference in the treatment group(P>0.05).There was significant statistical difference in the control group(P<0.01)The symptom scores were higher than before;the shortness of symptoms scores were not statistically different between the groups(P>0.05).There was no significant difference in the HRCT between the two groups(P>0.05).The score of the treatment group decreased,and the score of the control group showed a worse trend.In terms of lung function,the FVC%,Dlco%,and TLC%of the treatment group showed an increasing trend compared with that before treatment.The FVC%,Dlco%,and TLC%of the control group showed a downward trend compared with that before the treatment;the Dlco%decreased with the control group.The difference between the two groups was statistically significant(P<0.05).There was significant difference in the decrease of FEV1/FVC between the treatment group and the control group(P<0.05).There was a statistically significant difference between the treatment group and the control group in the FEV1/FVC group(P<0.05).There was no significant difference between the other groups(P>0.05).In terms of oxygen,there was no significant difference between the treatment group and the control group(P>0.05).In the 6-minute walk,there was no significant difference between the treatment group and the control group(P>0.05).There was a statistically significant difference between the two groups(P<0.05).The treatment group showed a trend of improvement and the control group showed a worsening trend.There was no significant difference in the treatment group(P>0.05),and there was statistical difference in the control group(P<0.05).The 6MWT ability was lower than before.There was no significant difference in grading difficulty between the groups(P>0.05).There was significant difference in the control group(P<0.05),and the dyspnea grade was increased.There was no statistical difference in the treatment group.P>0.05).The total score of SGQR in the treatment group was statistically different(P<0.05).There was no statistical difference in the control group(P>0.05).There was no significant difference between the groups(P>0.05).).Symptoms,activity limitation,and psychological status were statistically different in the treatment group(P<0.05),and there was no statistical difference in the control group(P>0.05).There was a statistical difference(P<0.05).Conclusion:Western medicine combined with traditional Chinese medicine Fuzheng Tongluo Recipe in the treatment of patients with non-acute aggravation of IPF pulmonary-kidney qi deficiency syndrome can improve some clinical symptoms and syndromes of patients,may delay the trend of lung function and imaging deterioration,improve patient exercise endurance Trends to improve the quality of life of patients.