Clinical Effectiveness Observation Of Acupuncture Combined With Traditional Chinese Medicine Tiaozhou Method In The Treatment Of Kidney-deficiency Type Of Polycystic Ovary Syndrome

Objective:The purpose of this study is to provide a treatment with more safety,effectiveness and economical value for patients with polycystic ovary syndrome（PCOS）.To achieve the goal,the author uses acupuncture combined with traditional Chinese medicine（TCM）Tiaozhou（regulating menstrual circadian rhythm）method on patients with kidney-deficiency type of PCOS,objectively evaluates the clinical effectiveness and safety of the method and explores the potential synergistic effect.Methods:From January 2018 to December 2018,84 patients with PCOS treated at the gynaecological department of Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine satisfied the requirements and were enrolled.They were randomly divided into treatment group（42 cases）and control group（42 cases）,both treated with TCM.While patients in the control group were treated with placebo acupuncture,those in the treatment group were served with real acupuncture.The course of treatment was three menstrual cycles.Indicators for observation and evaluation include menstrual conditions before and after treatment,TCM syndrome index,the six sex hormones+AMH,data from vaginal ultrasounds（including maximum intima thickness,maximum follicular diameter and follicular development and ovulation）and difference in basal body temperature.Results:（1）Menstrual cycle:1)in both groups,mean menstrual cycle after treatment was significantly shorter than that before treatment,with P<0.01;2)the difference between the two groups is also statistically significant（P<0.05）.（2）TCM syndrome index:1)Total scores in both groups were lower after treatment than before,and the difference was statistically significant（P<0.01）;2)the difference between the groups was also statistically significant（P<0.01）.（3）Sex hormones+AMH:1)There was no significant difference before and after E₂treatment in either group（P>0.05）;but the difference between the two groups was statistically significant（P<0.05）.2)There was no significant before and after FSH treatment in either group（P>0.05）.There was no significant difference between the two groups either（P>0.05）.3)LH levels after treatment in both groups were lower than those before treatment,and the difference was statistically significant（P<0.05）.The difference between the two groups was also statistically significant（P<0.05）.4)T levels after treatment in both groups were lower than those before treatment,and the difference was statistically significant（P<0.05）.There was no significant difference between the two groups（P>0.05）.5)The LH/FSH ratios in both groups were lower than those before treatment,and the difference was statistically significant（P<0.05）.The difference between the two groups was also statistically significant（P<0.05）.6)There was no significant difference in before and after AMH treatment（P>0.05）in either group.There was no significant difference between the two groups（P>0.05）.（4）Vaginal ultrasounds:1)The thickness of intima increased after treatment in both groups,but the difference was not significant（P>0.05）.There was no significant difference between the two groups at each time point（P>0.05）.2)The maximum follicle diameter increased after treatment in both groups.Difference in the control group at different time points was not statistically significant（P>0.05）,but that in the treatment group was（P<0.05）.Paired comparison showed that the maximum follicle diameter of the third menstrual cycle was significantly higher than that of the first menstrual cycle,and the difference was statistically significant（P<0.05）.Compared with the control group,the maximum follicle diameter in the treatment group was larger in the third menstrual cycles,and the difference was statistically significant（P<0.05）.There was no significant difference in the first and second menstrual cycles（P>0.05）.3)The total ovulation rate and mature follicle ovulation rate in the treatment group were higher than those in the control group,and the difference was statistically significant（P<0.01）.The non-ovulation rate in the treatment group was lower than that in the control group,and the difference was statistically significant（P<0.01）.There was no significant difference in small ovulation rate and LUFS rate between the two groups（P>0.05）.（5）Basal body temperature:The treatment group responded better than the control group in improving BBT（P<0.05）.（6）Total effectiveness:1)The total rate of TCM syndrome effectiveness in the control group was 83.3%,and that in the treatment group was 90.5%.The difference between the two groups was statistically significant（P<0.05）,indicating the treatment group responded better than the control group in improving the effectiveness of TCM syndromes.2)The total rate of effectiveness in the control group was 78.5%,and that in the treatment group was 90.4%.The difference between the two groups was statistically significant（P<0.05）,indicating that regarding comprehensive effectiveness,the treatment had a positive effect.Conclusions:Acupuncture combined with TCM Tiaozhou method can improve menstruation and TCM syndrome index of PCOS patients,regulate their endocrine and promote follicular development and ovulation,and have certain effects on improving endometrial thickness,leading to a better clinical effectiveness.The total rate of effectiveness in this study was 90.4%.