Analysis Of Related Factors Of Radioactive Oral Mucositis In Patients With Nasopharyngeal Carcinoma With Intensity Modulated Radiotherapy

Objective:This study to understand intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma(NPC)and the occurrence of inflammation of radioactive oral mucosa to explore major risk factors of inflammation of radioactive oral mucosa,in intensity modulated radiation therapy for patients with nasopharyngeal carcinoma(NPC)in the prevention of inflammation of radioactive oral cavity provides experience and relevant evidence,can aid in early identification of high-risk patients,medical staff and nursing measures of prevention and intervention in time.Methods:This is a non-experimental descriptive study and using the convenience sampling method.In this study,patients with nasopharyngeal carcinoma who underwent underwent intensity modulated radiation therapy in the department of oncology of a third-grade hospital in Nanchang City from May 2018 to October 2019 were selected as the research objects.Clinical indicators such as gender,age,occupation,educational level,alcohol consumption,smoking,BMI,TNM stage,oral PH value,oral care,use of antibiotics,chemical therapy and oral protectant were observed and recorded.SPSS 24.0 software was used for single factor analysis and multivariate Logistic regression analysis of related factors.Results:A total of 169 subjects were included in this study,including 146 cases(86.4%)of radioactive oral mucositis and 23 cases(13.6%)of non-radioactive oral mucositis.In the radiation oral mucositis group,14 patients(9.6%)were grade I,58(39.7%)were grade II,68(46.6%)were grade III,and 6(4.1%)were grade IV.There was no statistically significant difference between the two groups in gender,BMI,alcohol consumption,marital status,occupational nature and medical payment methods(P>0.05).In terms of age,smoking and education level,the differences between the two groups were statistically significant(P<0.05).There were statistically significant differences in disease stage,oral condition,combined chemotherapy,mucosalprotectant and oral PH prescription between the two groups(P<0.05).In terms of diabetes and white blood cell count,there was no statistically significant difference between the two groups(P>0.05).The results of multivariate unconditional logistic regression showed that the age(OR=1.085,95% CI =1.012-1.615,P=0.023),smoking(OR=1.274,95% CI=(1.095-2.007,P=0.008),the worse the oral hygiene was [good(OR=1.223,95% CI=1.098-2.077,P= 0.006),the worse(OR=1.367,95%CI=1.024-2.890,P=0.012)and the oral PH value <7.0(OR=1.728,95% CI=1.420~2.541,P=0.003)were significantly correlated with the occurrence of oral mucositis,which was an independent risk factor of oral mucositis in NPC patients with radiotherapy.Conclusion:The results of this study showed that the incidence of RIOM in nasopharyngeal carcinoma patients with intensity modulated radiation therapy was 86.4%.The results of multivariate unconditional logistic regression showed that age,smoking,oral hygiene,and oral PH were the risk factors for RIOM in NPC patients.For in the future in practical nursing treatment,analysis of patients with nasopharyngeal carcinoma after radiotherapy in high risk factors of the oral cavity mucous membrane inflammation,intensity modulated radiation therapy for different patients take different and targeted nursing intervention and health education,in order to reduce the radioactive oral mucositis in patients with nasopharyngeal carcinoma has important clinical significance.