Analysis Of Related Factors And Oral Health-related Quality Of Life In Patients With Radiation-induced Oral Mucositis

Objective:1.The related factors of radiation oral mucositis were analyzed.2.According to whether there is radiation mucositis after intensity modulated radiation therapy,we can judge whether there is difference in oral health and oral health-related quality of life.Methods:From October 2018 to December 2019,120 patients with head and neck cancer who were treated by IMRT in the second hospital of Shanxi Medical University and Shanxi Tumer Hospital were selected to collect general data(including general characteristics and cancer characteristics).Within one week after the end of radiotherapy,professional dentists checked the oral conditions of all patients and recorded the dental plaque index(PI),detection depth(PD),radiation-induced oral mucositis(RTOM)incidence and classification,record data.According to the presence of RTOM,the patients were divided into two groups:the group with RTOM and the group without RTOM.In addition,the OHIP-14 scale was filled in by the patients themselves to compare the oral health-related quality of life of the two groups.The data were analyzed by Mann Whitney U test and?~2test.Results:1.118 patients were treated with intensity-modulated radiotherapy(IMRT),97patients with RTOM,the incidence was 82.2%.The proportion of patients in grade II was42.27%,followed by grade III(31.96%),grade I(18.56%)and grade IV(7.21%).2.Single factor analysis showed that there was no significant difference in sex,drinking history,marital status,clinical stage,treatment and chronic history between patients with and without RTOM(P>0.05),The differences of smoking history(P=0.004)and BMI<18.5kg/m~2(P=0.009)were statistically significant.The results showed that only smoking history(OR,0.076;95%CI,0.076-0.876;P=0.03)had statistical significance.3.The median(lower,upper quartile)of PD value in the group with RTOM and without RTOM was 5(4,7)and 5(4,6)respectively,with no significant difference(P=0.805);the median(lower,upper quartile)of PI index was 2(1,3)and 1(0,2)respectively,and the difference was statistically significant.(P=0.041).4.The difference of oral health-related quality of life between the with RTOM group and the without RTOM group was statistically significant(P<0.05).There was no significant difference in the other three dimensions(P>0.05).Conclusion:1.The incidence of radiation-induced oral mucositis is high in patients with head and neck cancer after IMRT.Smoking is an independent risk factor for radiation-induced oral mucositis.2.Patients with RTOM after IMRT had poor oral health and lower quality of life related to oral health than those without RTOM.