Analysis Of The Impact Of Vaginal Microecological Environment On The Outcome Of Cervical HPV Infection

Objective: To explore the effect of vaginal micro-ecological environment on the outcome of cervical high-risk human papilloma virus(HR-HPV)infection,and to provide scientific basis for blocking the HPV infection process and preventing cervical cancer.Methods: 174 women has selected from Handan Central Hospital from September 2017 to March 2019,which has been diagnosed cervical persistent high-risk HPV infection(HR-HPV)and no cervical lesions.Followed-up for 6months and performed retrospective analysis.(1)Study one: According to the detection results of vaginal secretions,among the 174 subjects,56 cases had normal vaginal microecology,118 cases with vaginal microecological imbalance,64 received treatment for vaginitis and 54 did not receive treatment for vaginitis.Therefore,they had been divided into three groups for retrospective cohort study: Group A for normal vaginal microecological was 56 cases,group B for vaginal microecological imbalance standard vaginitis not in standard vaginitis treated was 54 cases,group C for vaginal microecological imbalance in standard vaginitis treated was 64 cases.Analyzing the three groups of HPV negative rate,and exploring whether the vaginal microecological environment affects persistent HR-HPV turning negative.(2)Study two: Excluding the interference of drug treatment of vaginitis,the remaining 110 subjects were divided into HPV negative group and non-transitive negative group according to their outcomes.Logistic regression model was used to analyze the differences in the vaginal microecological environment(lactobacillus,BV,TV,VVC,mycoplasma infection)between the two groups.Results:(1)Study one: General information was comparable without difference(P<0.05).The negative rate of HR-HPV was 71.43%(40/56)in group A,29.63%(16/54)in group B and 56.25%(36/64)in group C.Therefore,the negative rate of HR-HPV of the group A and group B were different and statistically significant(P<0.05).The negative rate of HR-HPV in the group B and group C were different and statistically significant(P<0.05).(2)Study two: The study showed that56 cases turned negative(50.91%)and 54 cases(49.09%)had not turn negative.(1)Univariate analysis of the basic information: There were statistically significant differences in age,contraceptive methods between the two groups(P<0.05);but there was no statistically significant difference in number of births,and the age of sexual life.(2)Univariate analysis of vaginal micro-ecological environment: BV,TV,VVC,lactic acid bacteria were statistically significant difference between the two groups(P<0.05);mycoplasma was not statistically significant difference between the two groups.(3)Factors with P < 0.05 in univariate analysis were included in binary logistic regression analysis.The results showed that contraceptive methods,BV and VVC were independent factors affecting HR-HPV infection.Conclusions:(1)Imbalance of vaginal micro-ecological environment was a risk factor for persistent HR-HPV infection,it could reduce the negative rate of HR-HPV infection.After treatment of vaginitis,the HR-HPV conversion rate was higher than untreated vaginitis.(2)BV,VVC and non-condom contraception were independent risk factors for cervical HR-HPV infection,which was not conducive to cervical HR-HPV negative.