Drug Resistance Analysis Of Acinetobacter Baumannii In Ningxia From 2016 To 2018

Objective To analyze the drug resistance of Acinetobacter baumannii in our hospital from January 2016 to December 2018 and the risk factors of Acinetobacter baumannii infection in intensive care unit,to provide reference for clinical doctors in our hospital to reasonably apply antibacterial drugs and control Acinetobacter baumannii infection in intensive care unit.Methods The strains were identified by microbial automatic analyzer,the drug sensitivity test was carried out by K-B method.The risk factors for infection of Acinetobacter baumannii isolated from intensive care unit were analyzed.Results A total of 999 strains of Acinetobacter baumannii were detected in our hospital from 2016 to 2018,with the lowest drug resistance rate to minocycline being42.8%,followed by the drug resistance rates to compound sulfamethoxazole and cefoperazone/sulbactam being 45.2% and 53.0%,respectively,and the rest being more than 75%.For 3 consecutive years,the drug resistance rate of the bacteria to compound sulfamethoxazole decreased significantly(p=0.00),while the drug resistance rates of minocycline(p=0.016)and amikacin(p=0.00)increased significantly.The drug resistance rate to cefoperazone/sulbactam increased from53.6% to 64.9%(p=0.004)from 2016 to 2017,and decreased from 64.9% to27.6%(p=0.00)from 2017 to 2018.the drug resistance rate of other antibacterial drugs did not significantly increase or decrease(p>0.05).The drug sensitivity analysis of Acinetobacter baumannii isolated from intensive care unit and non-intensive care unit from 2016 to 2018 shows that the drug resistance rate of Acinetobacter baumannii isolated from intensive care unit to 13 antibiotics is over 82%,and the drug resistance rate is higher than that of non-intensive care unit(p<0.05).Risk factors of Acinetobacter baumannii infection isolated from intensive care unit were analyzed as follows: various catheterization procedures(OR=7.672),diabetes mellitus(OR=4.143),carbapenem antibiotic use(OR=3.517),age(OR=0.898),gender(OR=0.632),and surgical history during hospitalization(OR=1.231).Conclusion Drug resistance of Acinetobacter baumannii isolated from our hospital from 2016 to 2018 was serious.The drug resistance of Acinetobacter baumannii in different hospitals is found to be different by comparing with the monitoring data of bacterial drug resistance in different regions.Therefore,clinicians should consider the epidemiological characteristics and drug resistance of the regions and hospitals before selecting antibiotics,and at the same time use antibiotics cautiously according to the indications of drug sensitivity test results.Diabetes mellitus,the use of carbapenem antibiotics and various catheterization procedures(respiratory tract,urinary tract,etc.)are risk factors for Acinetobacter baumannii infection in intensive care unit patients in our hospital.