Analysis Of Bone Mineral Density Changes And Related Influencing Factors In Type 2 Diabetes Patients Of Han Nationality In Xining Area

Objective:By studying the changes of bone density and related risk factors for the development of type 2 diabetes patients in Xining region,a new idea is provided for the early prevention and treatment of diabetic osteoporosis in this region,so as to avoid the occurrence of fractures with severe complications of osteoporosis.Methods:A total of 307 han patients with type 2 diabetes who were hospitalized in our hospital from November 2018 to January 2020 were collected.General data and biochemical indicators of all subjects were collected.BMD of lumbar spine,femoral neck,hip and left forearm were measured by dual-energy X-ray absorptiometry.According to the diagnostic criteria of OP recommended by WHO,all patients meeting the inclusion criteria were divided into 59 patients with normal bone mass.Decreased bone mass in 136 patients;Osteoporosis group: 112 cases.SPSS21.0 was used for statistical analysis,and α =0.05 was the test level.Results:1.Among all the subjects,there were 196 males and 111 females,112 in the osteoporosis group,136 in the bone mass reduction group and 59 in the normal bone mass group.There were statistically significant differences between the three bone mass status groups for gender(P<0.01).Furthermore,the detection rate of osteoporosis in women was significantly higher than that in men.2.In the total population of T2 DM,the age of osteoporosis group was significantly higher than that of normal bone mass group(P<0.05).Waist circumference of the osteoporosis group was significantly lower than that of the normal bone mass group(P<0.05).The BMI level of the osteoporosis group was significantly lower than that of the normal bone mass group and the bone mass reduction group(P<0.05).FBG levels in the osteoporosis group were higher than those in the normal and reduced bone mass groups(P<0.05).The level of 2hPBG in the osteoporosis group was higher than that in the normal bone mass group and the bone mass reduction group(P<0.05);At the same time,the level of 2hPBG in the normal bone mass group was lower than that in the reduced bone mass group(P<0.05),indicating that the level of 2hPBG was statistically significant between the three groups(P<0.05).UA levels in both the osteoporosis group and the osteopenia group were lower than those in the normal bone mass group(P<0.05),ALP in both the osteopenia group and the osteoporosis group was higher than that in the normal bone mass group(P<0.05).3.Lumbar BMD was positively correlated with BMI and UA(P<0.05),negatively correlated with 2hPBG and FBG levels(P<0.05);BMD value of femoral neck was positively correlated with BMI,blood phosphorus and UA levels(P<0.05),which were negatively correlated with age,PTH,ALP,2hPBG and FBG levels(P<0.05);Hip BMD was positively correlated with BMI,blood phosphorus and UA(P<0.05),hip BMD value was negatively correlated with age,PTH,ALP,2hPBG,and FBG levels(P<0.05);BMD value of left forearm was positively correlated with serum phosphorus and UA levels(P<0.05),negatively correlated with age,PTH and FBG levels(P<0.05).4.Logistic regression analysis showed that female gender,age,ALP,FBG and 2hPBG were risk factors for OP in patients with T2 DM,while BMI was a protective factor for osteoporosis in patients with type 2 diabetes.Conclusion:1.The proportion of women in osteoporosis group was higher than that of men.The age of the osteoporosis group was older,while the waist circumference and BMI were lower than those of the normal bone mass group.The ALP,fasting blood glucose and 2h postprandial blood glucose levels of the osteopenia group and the osteoporosis group were higher than those of the normal bone mass group.2.Female gender,age,ALP,FBG,and 2hPBG are risk factors for the development of OP in T2 DM patients,while BMI is a protective factor for the prevention of osteoporosis in type 2 diabetes patients.