Expression Of Serum Pepsinogen And Gastrin-17 In Different Gastric Diseases

Objective: The expressions of serum Pepsinogen(PG),The ratio of Pepsinogen I and Pepsinogen II(PGR)and gastrin-17(gastrin-17,g-17)in different gastric diseases were analyzed.Methods: Testing the clinical value of serum Pepsinogen(PG),The ratio of Pepsinogen I and Pepsinogen II(PGR)and Gastrin-17(G-17)in the diagnosis of benign and malignant gastric diseases was analyzed.Results:1.In the chronic gastritis group,gastric hyperplastic lesions group and the early gastric cancer group,The G-17 level increased progressively.The difference of Serum G-17 level between the chronic gastritis group and the early gastric cancer group was statistically significant(P<0.05),statistically significant differences in Serum G-17 levels between the gastric hyperplastic lesions group and the early gastric cancer group(P<0.05),and no statistically significant differences in Serum G-17 levels between the chronic gastritis group and gastric hyperplastic lesions group(P>0.05).2.The Serum PGI level decreased gradually between the chronic gastritis group,the gastric hyperplastic lesions group and the early gastric cancer group.Among them,there was significant statistical difference in Serum PGI level between the chronic gastritis group and the early gastric cancer group(P<0.05),no significant difference in Serum PGI level between the chronic gastritis group and the gastric hyperplastic lesions group(P>0.05),and no significant difference in Serum PGI level between the gastric hyperplastic lesions group and the early gastric cancer group(P<0.05).3.The Serum PGII level decreased gradually in the chronic gastritis group,the gastric hyperplastic lesions group and the early gastric cancer group,but there was no statistical difference between the groups(P>0.05).4.The PGR values of the chronic gastritis group,the gastric hyperplastic lesions group and the early gastric cancer group decreased gradually.The PGR value of the chronic gastritis group was significantly higher than that of the early gastric cancer group,and the difference was statistically significant(P<0.05).The PGR value of the gastric hyperplastic lesions group was higher than that of the early gastric cancer group,and the difference was statistically significant(P<0.05).5.The area under the ROC curve of Serum PGI in the diagnosis of gastric precancerous lesions was 0.682(0.545-0.818),the optimal critical value was 172.505ng/ml,the sensitivity was 88.7%,and the specificity was 47.8%.The area under the ROC curve of Serum PGII in the diagnosis of gastric precancerous lesions was 0.598(0.477-0.749),the optimal critical value was 14.01ng/ml,the sensitivity was 71%,and the specificity was 56.5%.The PGR value was 0.696(0.573-0.818)for the diagnosis of gastric precancerous lesions under the ROC curve,with an optimal critical value of 15.925,a sensitivity of 67.7%,and a specificity of 65.2%.6.The area under the ROC curve of Serum G-17 in the diagnosis of early gastric cancer was 0.764(0.646-0.883),the optimal critical value was 17.905pmol/l,The sensitivity and specificity were 82.6% and 69.4% respectively.7.With age 60 as the critical value,it was divided into ≤60 years group and >60 years group.Serum G-17 in the > 60-year-old group was significantly higher than that in the ≤ 60-year-old group,and the difference was statistically significant(P<0.05).The level of Serum PGI in group ≤60 years old was higher than that in group >60,but the difference was not statistically significant(P>0.05).Serum PGII and PGR values of ≤60 years old group were lower than those of 60 years old group,and the difference between groups was not statistically significant(P>0.05).8.Serum levels of G-17 of male group was obviously lower than female group,and data with a statistically significant difference(P<0.05).The serum PGI and PGR of the male group were higher than that of the female group,but the difference between the two groups was not statistically significant(P>0.05).Serum PGII in the male group was lower than that in the female group,but there was no statistically significant difference between the groups(P>0.05).Conclusions:1.PGI,PGR and G-17 can be used for screening for precancerous diseases and early gastric cancer.Among them,PGI and PGR have greater predictive value for gastric precancerous diseases,while G-17 has greater predictive value for early gastric cancer.2.The level of serum gastrin-17 in women over 60 years old is higher than that in men.