The Value Of Pepsinogen And Gastrin 17 In The Early Screening Of Gastric Precancerous Lesions

Objective:To explore the changes of serum pepsinogen(PG)and gastrin 17(G17)in intraepithelial neoplasia(INE),and to calculate the optimal cut-off value of suitable serological markers of INE,in order to further improve the early detection rate and diagnostic accuracy of cancer.Develop early gastric cancer screening in line with China’s national conditions and epidemiological characteristics of gastric cancer.Method:All the enrolled cases were examined by gastroscopy and divided into healthy control group,atrophic gastritis(AG),INE,gastric cancer(GC).PG and G17 levels were tested by sandwich enzyme-linked immunosorbent assay(ELISA),which was performed strictly according to the operation;the ROC curve of PG and G17 in the group of INE and GC was drawn,and the optimal cut-off value of the serological index for screening INE and GC was calculated.Result:Compared with the healthy control group,the PGR level in the INE group and the GC group was significantly lower,the PGⅡlevel in GC group was significantly higher,and the of G17 level in the LGINE group was significantly decreased.The cut-off value of PGR for screening INE was ≤11.605(sensitivity88%,specificity 56%).The cut-off value of G17 for screening LGINE was ≤2.845pmol/L(sensitivity 60%,specificity 70.2%);The AUC of PGR combined with G17 was significantly higher than that of PGR,PGR combined with PGI,PGR combined with PGⅡ(P<0.05).However,compared with the multi-index AUC,there was no significant difference;the cut-off value of PGR screening for HGINE was ≤12.415(sensitivity 100%,specificity 51.6%).The AUC of PGR combined with PGI was significantly higher than that of PGR and PGR combined with PGII(P<0.05).Although it was higher than that of PGR combined with G17,as with the multi-index AUC,there was no statistical significance;the cut-off value of PGⅡ,PGR and G17 for screening GC was ≥10.775 ug/L(sensitivity 88.9%,specificity 54%),≤7.41(sensitivity 60%,specificity 86.4%),≥9.98 pmol/L(sensitivity 55.6%,specificity 70.4%).Conclusion:PGI,PGⅡ,PGR and G17 can be used as indicators for screening early gastric cancer and precancerous lesions.Combined diagnosis of G-17 and PGR can improve the accuracy of PGR in the diagnosis of LGINE.PGI combined with PGR can improve PGR The correct rate of diagnosis of HGINE.