| 【Objective】To understand the possible relationship between different constitutions of patients with polycystic ovary syndrome and vaginal color Doppler ultrasound morphology and blood flow parameters,and to analyze the correlation between different constitutions of patients with polycystic ovary syndrome and sex hormone indexes,so as to provide objective basis for the diagnosis and treatment mode of syndrome differentiation combined with body differentiation,and explore the feasibility of early intervention and more optimized individualized diagnosis and treatment scheme of this diagnosis and treatment mode.【Method】From January 2019 to December 2019,88 patients with polycystic ovary syndrome(PCOS)were admitted to the gynecology clinic and color Doppler ultrasound room of the Affiliated Hospital of Cheng Du of traditional Chinese medicine.The basic situation questionnaire survey and the constitution judgment of traditional Chinese medicine were carried out to analyze the distribution of different constitution of traditional Chinese medicine in patients with PCOS.The clinical manifestations,sexual hormone indexes,ultrasonic morphology,blood flow parameters and other data were collected to analyze the correlation between different constitution of patients with PCOS and them.The measurement data and observation indexes are input into excel table for classification and arrangement.Finally,spss25.0software is used for data analysis,and relevant conclusions are drawn from the analysis results.【Result】(1)88 patients with PCOS were collected in this study,including 20 cases,15 cases,14 cases,12 cases,11 cases and 7 cases of qi stagnation,phlegm dampness,damp heat,yang deficiency,blood stasis and qi deficiency.Due to the low proportion of yin deficiency,mild nature and special nature,4 cases,4 cases and 1 caserespectively were not included in the study.(2)The incidence of overweight and obesity(46.7%,13.3%)in PCOS patients with phlegm-dampness is higher than that in other physical types.Compared with yang deficiency,the Body mass index BMI of PCOS patients with phlegm-dampness mass is p<0.05.(3)In this study,the average Ovarian volume V of patients with damp-heat PCOS and phlegm-dampness PCOS is the largest,9.13±1.63 ml and 8.37±1.69 ml respectively,while the average ovarian volume of patients with yang-deficiency PCOS is the smallest,5.92±1.60 ml.(4)In this study,the peak systolic blood flow velocity(Peak Systolic Blood Flow Velocity PSV)of the left and right ovaries of PCOS patients with qi stagnation is higher than that of other constitution types.End diastolic velocity EDV of left and right ovaries in patients with damp-heat PCOS is higher than other constitutions,while ovarian Resistance index RI and ovarian Power index PI of patients with phlegm-dampness PCOS are higher than other constitutions.In the comparison of right ovary PSV of PCOS patients,the comparison of qi stagnation quality with yang deficiency quality and qi deficiency quality,p < 0.05;Compared with yang deficiency,phlegm-dampness quality is p<0.05.In the two-to-two comparison of PSV in the left ovary,the qi deficiency quality is compared with the qi depression quality,phlegm-dampness quality and damp-heat quality,p<0.05.The difference between qi stagnation and yang deficiency was p<0.05.In the comparison of EDV in right ovary of PCOS patients,qi deficiency,damp-heat and phlegm-dampness were compared,P< 0.05;In the two-to-two comparison of EDV in the left ovary,the moist heat and yang deficiency were compared,p < 0.05;The difference between qi deficiency and phlegm dampness was p < 0.05.In the pairwise comparison of PI in the left ovary of PCOS patients,the phlegm-dampness quality is compared with the blood stasis quality,p<0.05.In the two-to-two comparison of RI in the left ovary of PCOS patients.Compared with phlegm-dampness,damp-heat and yang-deficiency,blood stasis isp<0.05.(5)Luteinizing hormone LH and LH/ Follicle stimulating hormone FSH in patients with Yang deficiency PCOS are higher than other constitutions,while FSH in patients with Qi deficiency PCOS is higher than other constitutions.FSH of PCOS patients with blood stasis is lower than that of damp-heat(p<0.05).Compared with phlegm-dampness and damp-heat quality,LH of PCOS patients with yang deficiency quality is p<0.05.The LH/FSH of PCOS patients with qi stagnation is lower than that of damp heat,p<0.05.(6)hyperandrogenism in this study mainly occurred in PCOS patients with qi stagnation and phlegm dampness,and t in PCOS patients with phlegm dampness was lower than that of damp heat and yang deficiency(p<0.05).(7)The correlation between different constitution types and risk factors of PCOS patients in this study: correlation with qi stagnation: PSV(OR=1.479,P =0.001);Related to phlegm-dampness quality: T(OR=1.047,p=0.026),BMI(OR=1.218,p=0.022),PI(OR=3.124,P = 0.024);Related to damp-heat quality: V(OR=1.296,p =0.037);Related to yang deficiency: LH/FSH(OR=1.786,p=0.033).【Conclusion】1.The constitution types of 88 patients with polycystic ovary syndrome in this study are mainly qi stagnation,phlegm dampness and damp heat.2.The probability of obesity or androgen level rise in PCOS patients with phlegm-dampness is higher than that in PCOS patients with other constitutions.3.There are differences in ultrasonic morphology and blood flow parameters among patients with polycystic ovary syndrome of different constitutions.4.The constitution type of patients with polycystic ovary syndrome has certain relation with ultrasonic morphology,blood flow parameters and sex hormone indexes.5.The clinical application of transvaginal color Doppler ultrasound and blood flow parameters,combined with sex hormone indicators,have certain auxiliary effects on the diagnosis and treatment mode of PCOS. |
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