The Study And Analysis Of Fraction Exceretion Of Uric Acid In Patients With Hyperuricemia In Chengde

Objective:To clarify the clinical classification of patients with Hyperuricemia in Chengde,and provide theoretical support for clinicians to guide in choosing uric acid-lowering drugs rationally.Further studying the relevant factors which affect the fraction exceretion of uric acid of HUA patients,preventing or reducing the occurrence and development of Hyperuricemia and its comorbidities.Methods:A total of 200 patients with Hyperuricemia who were hospitalized in the endocrinology department or visited outpatient or Health Checkup Center of Chengde Central Hospital from December 2018 to October 20-19 were executively enrolled.Their renal function were normal[e GFR≥60ml/(min·1.73m2)].Aaccording to whether they had metabolic syndrome(MS),patients were divided into two groups:simple Hyperuricemia group(HUA group,n=100)and Hyperuricemia combined with metabolic syndrome group(HUA+MS group,n=100).Collecting general demographic information of all patients,measuring height,weight and blood pressure,calculating body mass index(BMI).All patients continue a normal purinediet for 3 days,collecting theirs 24 hours of urine,measuring 24 hours of uric acid(24h Uua)and 24 hours of creatinine(24h Ucr).Taking fasting venous blood,and placeing the blood in a vacuum blood collection tube which did not contain anticoagulant and left for 30 minutes.After the completion of agglutination,centrifuging at 3500 r/min for 10 minutes.Hitachi-7600 automated biochemical analyzer was used for detecting of uric acid,creatinine,blood urea nitrogen,total cholesterol,tyiglyceride,high density lipoprotein cholesterol,low-density lipoprotein cholesterol,fasting bloodglu-cose and other biochemical Indicators by professional doctors.The uric a-cid and creatinine reagents were supplied by Nippon Kazuhiro KogyoCo.,Ltd.,respectively using the uricase-peroxidase method and the sar-cosi ne oxidase method.Glucose oxidase method is used for blood glucoseme asurement,reagents,calibrators and quality control materials are supporting items.Recording all datas,calculating fraction exceretion of uric acid.(FEU A=(blood.creatinine*uric.acid)/(blood.uric.acid*urine.creatinine)).Conducting clinical classification of patients with Hyperuricemia by FEUA,And obtaining the composition ratio of clinical classification of HUA.Comparing.general information,biochemical indicators,serum uric acid and FEUA of the two groups;Analyzing uric acid,creatinine and FEUA between different subgroups ofpatients of Hyperuricemia combined with metabolic syndrome,as well asthe effects of blood pressure,blood lipids,blood glucose,body mass index andother indicators on serum uric acid and FEUA.We applied Pearson analysis to detect the correlation between FEUA and other indicators.Independent sample t test ananlyze the differences of UA and Cr of blood andurine as well as FEUA levels of different subgroups in patients of HUA combined with MS group.the difference was statistically significant with(bilateral)P<0.05.Results1.The clinical classification of patients with Hyperuricemia in Chengde is mainly composed of poor excretion,which accounts for 84%,amon g which,males accounts for 66% and females accounts for 34%.The age of onset concentrates on the range from 30 to 60 years old,and is prone to Middle-aged men and postmenopausal women.2.The comparison of general conditions of the two groups of patientsCompared with the control group,the age levels of HUA+MS group was statistically significant(P<0.05).There was no significant difference in gender,smoking and alcohol consumption(P>0.05).3.The comparison of biochemical indexes between two groups of patientsCompared with the control group,the BMI,Waist,FBG,TG,TC,andLDL-C levels of the HUA+MS group were significantly higher(P<0.01 or P <0.05).There was no significant difference in SBP and DBP(P>0.05).4.The comparison of serum uric acid,creatinine and uric acid excretion scores between two groupsCompared with the control group,serum uric acid levels of HUA+MS group were significantly higher,the difference was statistically significant(P<0.01);the urine creatinine of 24 hour was higher,while the urine uric acid of24 hour fraction exceretion of uric acid were lower,,the difference was statistically significant(P<0.05).There was no significant difference in serum creatinine level(P>0.05).5.The Pearson analysis between fraction exceretion of uric acid and other indicatorsThe level of FEUA was negatively correlated with BMI,FBG,SUA,TG,LDL-C,24 h Ucr(P<0.05),and positively correlated with SCr,24 h Uua(P<0.05);while the level of FEUA has no significant correlation with HDLC,DBP,SBP and TC(P>0.05).6.The comparison of level of serum uric acid,creatinine and FEUA among subgroups of patients in HUA+MS groupCompared with Hyperuricemia group,there was no significant difference in the levels of SUA and FEUA of Hyperuricemia with hypertension(P>0.05).While,the level of serum uric acid of patients in other groups were higher and the level of FEUA and 24 h Uua were lower,the difference was statistically significant(P<0.05 or P<0.01).Conclusions1.The clinical classification of patients with Hyperuricemia in Chengde is mainly composed of poor excretion,which accounts for 84%.2.The level of FEUA of patients with Hyperuricemia complicated with Metabolic syndrome were significantly lower than those with Hyperuricemia,suggesting that the uric acid excretion ability of HUA combined with metabolic syndrome is lower than those with HUA.