Hyperuricemia And Its Related Factors In Children With Primary Nephrotic Syndrome

Objective:The aim of present study is to evaluate the incidence of hyperuricemia and its related impact factors in children with primary nephrotic syndrome(PNS).Method:The clinical data of 97 children diagnosed with PNS were retrospectively collected.From them,12 patients with obesity,diabetes,metabolic syndrome or cardiovascular disorders were excluded,and 85 patients were recruited finally.These 85 patients were divided into two groups:hyperuricemia group(HUA)and normal uric acid group(NUA),and their clinical feature and laboratory findings were collected and compared,including serum platelet,erythrocyte sedimentation rate,serum uric acid,serum creatinine,serum urea nitrogen,serum cystatin C,serum triglyceride,serum cholesterol,serum Albumin,blood fibrinogen,D-dimer,urine beta 2 microglobulin,urinary Albumin,urine protein IgG,24 hours urinary transferrin,uric acid,24 hours urine protein,serum uric acid/blood creatinine,creatinine clearance,clearance of uric acid,uric acid excretion fraction differences.Logistic Regression analysis was used to analyze the relationship between the serum concentration of uric acid and other biochemical indicators.Result:43(50.6%)cases were recruited to HUA group and 42 in NUA group.In general,there was significant difference in BMI between two groups among clinical manifestations.Further,serum Albumin was decreased in HUA group than in NUA group.Serum Albumin was lower in HUA group than that in NUA group.24hr urine excretion of uric acid(24H Uua),ratio of serum uric acid to serum creatinine(Sua/Scr)was higher in HUA group than that in NUA group,while uric acid clearance rate(Cua)and fractional excretion of uric acid(FEua)was lower in the HUA group than that in NUA group.For correlation analysis,FEua and Alb were risk of factor hyperuricemia(OR=1.309 and OR=1.120 respectively)by logistic regression analysis.Conclusion:The incidence of hyperuricemia in children with PNS is high,and the main reason for the hyperuricemia in children with PNS is the reduction of uric acid excretion,which might be caused by renal tubular dysfunction.It worth pay more attention on its risk factors,timely prevention and control work.