Comparison Between BiPAP And NIPPV Effects Of Extubation And Withdrawal In Very Low Birth Weight Newborns

Objective: To compare the efficacy of two different ventilation modes sequence,NIPPV or BiPPV,in the treatment of very low birth weight infants after withdrawal.Methods: a retrospective study was conducted on 57 cases of VLBW intubated in the first neonatal ward of shengjing hospital affiliated to China medical university from January to December 2019,and the patients were divided into NIPPV group(35 cases using NIPPV+NCPAP strategy)and BiPAP group(22 cases using BiPAP+NCPAP strategy)according to the non-invasive assisted ventilation mode and sequence after removal.General information,recent indicators(blood gas PH,PaCO2,PaO2/FIO2,and withdrawal failure rate at 1 and 6 h after ventilation)and long-term indicators(mechanical ventilation time and incidence of related adverse complications)were compared between the two groups.Results: The withdrawal failure rate of the NIPPV group was 11.43(4),significantly higher than that of the BiPAP group 4.55(1),but P=0.679.There was no significant difference between the two groups.The NIPPV group was 5.8(2,10),38(27,51)and49(38,57),respectively,in terms of non-invasive ventilation time,oxygen use time and hospitalization days.The BiPAP group was 4.2(2,9),34(17.75,44.50)and 43(36.25,50),respectively.The incidence of intracranial hemorrhage,neonatal retinopathy(ROP),broncho-pulmonary dysplasia(BPD)and other adverse complications in the NIPPV group was significantly higher than that in the BiPAP group,while the incidence of white matter injury in the BiPAP group was 27.27(6)higher,but none of the above was statistically significant.Conclusion: There was no significant difference in the clinical efficacy of sequential treatment with NIPPV or BiPAP after extubation of very low birth weight infants.