Analysis On The Prevalence Of Retinopathy And Its Related Factors In 3404 Patients With Type 2 Diabetes Mellitus

Objective:To analyze the prevalence of Diabetic Retinopathy(DR)in patients with type 2Diabetes Mellitus(T2DM),the relevant influencing factors and correlation degree of DR,and the risk analysis of coronary heart disease,hypertension,cerebral infarction and foot ulcer in patients with type 2 diabetes mellitus,so as to provide theoretical basis for diabetic retinopathy.Methods:Through the medical record data,this study collected between January 2010 and December 2016,the Third in Anhui Medical University Hospital(the First People's Hospital of Hefei)of the clinical data of 6000 cases of hospitalized patients,using Epi Data software for data entry incorporated into a complete database,using a normative selection criteria ultimately selected 3404 cases,according to the result of ophthalmology consultation,divided the patients into the non-diabetic retinopathy group(group A group/NDR),non-proliferative diabetic retinopathy group(group B/NPDR group),retinopathy proliferation period group(group C/PDR group)3groups,Among them,there were 2562 cases in the non-retinopathy group,716 cases in the non-proliferative retinopathy group and 126 cases in the proliferative retinopathy group.Records of all patients clinical data(gender,age,height,weight,smoking history,drinking history,family history of diabetes,coronary heart disease,hypertension,cerebral infarction medical history,history of foot ulcers,etc.)and related laboratory tests(cholesterol,low density lipoprotein cholesterol(LDL-C),high-density lipoproteincholesterol(HDL-C),glycosylated hemoglobin,fasting blood glucose,blood urea nitrogen,serum creatinine,uric acid,blood triglycerides,cereal third transaminase,aspertate aminotransferase,blood sugar 2 hours after meal,total bilirubin,etc.),eye exam results and the prevalence of DR.The prevalence of DR was obtained,and the similarities and differences of clinical data and clinical indicators among the three groups of patients were compared,as well as the correlation with retinopathy,the independent risk factors of DR were obtained,and the incidence of coronary heart disease,hypertension,cerebral infarction and foot ulcer in the three groups were compared.Results:1.In this study,there were 2562 cases(75.3%)in the NDR group,716 cases(21.0%)in the NPDR group,and 126 cases(3.7%)in the PDR group.The prevalence of diabetic retinopathy was 24.7%(842/3404).2.Description of each group:2.1 NDR group,the clinical data NPDR group,the PDR group in comparison: gender,history of smoking,drinking,cholesterol,low-density lipoprotein cholesterol(ldl-c),high-density lipoprotein cholesterol(hdl-c),glycosylated hemoglobin,fasting glucose,duration,body mass index(bmi),systolic pressure,diastolic blood pressure,blood urea nitrogen,blood uric acid,triglyceride,aspertate aminotransferase,total bilirubin,difference between three groups was statistically significant(P < 0.05).2.2 Pairwise comparison between groups was conducted,P value was compared with the corrected P value(0.05/3),and the following results were obtained:Compared with group A,gender,smoking history,drinking history,course of disease,body mass index,systolic blood pressure,blood urea nitrogen,blood uric acid,glutamine transaminase and total bilirubin were significantly different in group B(P <0.017).There were statistically significant differences in cholesterol,LDL,uric acid and triglyceride between group C and group A(P < 0.017).Compared with group B,group C showed statistically significant differences in cholesterol,LDL,hemoglobin a1 c,uric acid and triglyceride(P < 0.017).2.3Course of disease,body mass index,glycosylated hemoglobin,triglyceride and uric acid were positively correlated with the prevalence and severity of DR,while total bilirubin was negatively correlated with it.The incidence and severity of DR were higher in men than in women.3.High triglycerides,high glycated hemoglobin,high uric acid and disease duration were independent risk factors for DR(P < 0.05),including triglycerides(OR=1.110,P=0.000),glycated hemoglobin(OR=1.087,P=0.000),serum uric acid(OR=1.003,P=0.000)and disease duration(OR=1.002,P=0.000).4.The risk of hypertension,coronary heart disease,cerebral infarction and foot ulcer in the DR group was higher than that in the NDR group,and the risk of disease in the PDR group was higher than that in the NPDR group.Conclusion:The prevalence of retinopathy in patients with type 2 diabetes is 24.7%,and hyperlipidemia,hyperglycemia,hyperuricemia and diabetes are independent risk factors for DR.Course of the disease?body mass index?Hb A1c?triglyceride and uric acid was positively correlated with the prevalence and severity of DR,while total bilirubin was negatively correlated with it.The incidence and severity of DR were higher in men than in women.The higher the severity of DR,the higher the risk of hypertension,coronary heart disease,cerebral infarction and foot ulcer.Controlling the risk factors of DR can delay the development of DR.