Effect Of Smoking On Coronary Artery Disease In Male Patients With Coronary Heart Disease

According to the Chinese cardiovascular disease report published in the Chinese Journal of circulation in January 2018,the prevalence of cardiovascular disease(CVD)in China is on the rise.Global epidemiology estimates that by 2030,an estimated 23.6 million people will die of CVD each year.CVD is not only the main cause of premature death in the world,but also the leading cause of death in China Coronary heart disease(CHD)is one of the most common diseases in CVD.According to the clinical characteristics,coronary heart disease can be divided into acute myocardial infarction(AMI)(including acute ST-segment elevation myocardial infarction and non-ST segment elevation myocardial infarction).stable angina pectoris(SA)and unstable angina pectoris(unstable angina),There were significant differences in treatment strategy and risk degree among different types of UA.The occurrence.severity,and clinical classification of coronary heart disease are related to smoking,hypertension,diabetes,dyslipidemia,age,family history,and other risk factors.Smoking is one of the world’s recognized independent risk factors for CHD.According to the epidemiological survey,there are about 1 billion adults smoking in the world,and China has the largest number of smokers,with more than 300 million smokers,most of whom are male smokers.Regression analysis of risk factors showed that about 11%of cardiovascular disease deaths were attributed to smoking.In the past few decades,the risk factors and pathogenesis of coronary heart disease(CHD)have been studied in depth.However,there is no detailed data on the relationship between smoking and the severity of coronary artery disease in Chinese male patients.Objective:To study the clinical effect of the method objective to investigate the effect of smoking on the severity of coronary artery disease in male patients with coronary heart disease.Methods:A retrospective study was conducted to collect 525 male patients with coronary heart disease who were hospitalized in the Department of cardiovascular medicine of our hospital from January 2018 to June 2019.After completing relevant examinations and eliminating contraindications,all patients underwent selective coronary angiography.The results showed that at least one coronary artery stenosis degree was more than 50%,and the clinical classification and related data of patients with coronary heart disease were recorded.The patients were divided into a smoking groups(362 cases)and non-smoking groups(163 cases)according to the smoking index(smoking age × daily smoking number).The general information and clinical classification of coronary heart disease between the two groups were compared.There were 163 cases in the non-smoking group(smoking index 0 groups),and the smoking group included two subgroups:0<smoking index<400 groups(99 cases)and smoking index≥400 groups(263 cases).The patients in the smoking group were further divided into smoking cessation group(smoking cessation time≥1 year)(151 cases)and non-smoking group(211 cases)according to whether they had quit smoking or not.All data were analyzed by spss24.0 statistical software.The measurement data of normal distribution were expressed as(x±s),and the comparison between groups was conducted by independent sample t-test;the measurement data of non-normal distribution was represented by M(P25,p75),and the comparison between groups was conducted by nonparametric rank-sum test.The count data were expressed by frequency,and the comparison between groups was performed by chi-square test.P<0.05 means there is a difference,with statistical significance.Results:1.There is a statistically significant difference in the clinical classification of coronary heart disease between the smoking group and the non-smoking group(P<0.05).The incidence of acute myocardial infarction in the smoking group(46%)is significantly higher than that of the non-smoking group(30%).2.The resting heart rate,white blood cell count,troponin I,CK-MB,uric acid and LDL of coronary heart disease patients in the smoking group were significantly different from those in the non-smoking group(P<0.05),and the resting heart rate,white blood cell count,troponin I,CK-MB,uric acid and LDL in the smoking group were higher than those in the non-smoking group.There was no significant difference in lymphocyte count,red blood cell count,hemoglobin,platelet count,creatinine,urea nitrogen,fasting blood glucose,HDL,alt,AST between the smoking group,and non-smoking group(P>0.05).3.There were statistically significant differences in the number of coronary artery lesions in the smoking index 0 groups,0<smoking index<400 group and smoking index≥400 groups.After the event,multiple comparisons showed that the number of coronary artery lesions in the 0<smoking index<400 groups and the smoking index≥400 groups were more than those in the smoking index 0 group(P<0.05),but there was no significant difference between the 0<smoking index<400 group and the smoking index>400 groups(P>0.05).4.Comparison of Gensini scores of different smoking index groups showed that Gensini scores of 0<smoking index<400 group and smoking index smoking index>400 groups were higher than those of smoking index 0 groups(P>0.05),and Gensini score of smoking index>400 groups was also greater than that of 0<smoking index<400 group,with a significant statistical difference(P<0.05).5.The number of coronary artery lesions and Gensini scores in the smoking cessation group and non-smoking group were compared.The results showed that the difference of coronary artery lesion number and Gensini score between smoking cessation group and the non smoking group was statistically significant,and the number of coronary lesion branches and Gensini scores in the smoking cessation group was less than those in non-smoking group.Conclusion:1.The incidence of AMI,white blood cell count,troponin I and CK-MB in the smoking group were significantly higher than those in the non-smoking group;2.The degree of coronary artery disease in male patients with coronary heart disease in the smoking group was higher than that in the non-smoking group,which suggested that the degree of coronary artery disease in male patients with coronary heart disease would be gradually aggravated with the extension of smoking time and the increase of smoking amount(Branch);3.The severity of coronary artery disease in male patients with coronary heart disease in the smoking cessation group was lower than that in the non-smoking group,indicating that the risk of coronary heart disease in the smoking cessation group had a downward trend,and some indicators would be improved or even normal;4.Quitting smoking can reduce the risk of coronary heart disease for smokers,and smokers’awareness of quitting should be promoted and strengthened.