| Objective:By observing the clinical efficacy of acne mixture in treating lung and stomac h fever acne,and its experimental study on the regulation of TNF-α,IL-6,IL-1β,and testosterone in rabbit serum,the mechanism of its treatment for acne was exp lored..Method:1 Clinical study: 60 patients meeting the criteria for inclusion were selected and di vided into a treatment group and a control group using a simple random method,with 30 cases in each group.The treatment group was given oral acne mixture +5% peroxybenzoyl gel for external use in the hospital,and the control group was g iven doxycycline hydrochloride capsules + 5% peroxybenzoyl gel for external use f or 6 weeks.The improvement of the condition was recorded every 2 weeks,and th e follow-up was performed 1 month after the end of the treatment to understand th e recurrence of the patient’s condition.2 Animal experimental research: 44 rabbits were randomly divided into: 7 normal c ontrol groups,37 models were made,and coal tar was applied to the inner side of the left ear of model animals,0.5ml / time for 14 days.The inoculation of Propio nibacterium acnes was started on the 7th day after modeling(inoculated at the plac e where coal tar was applied)for 5 consecutive days,and a total of 50 uL per rabb it was required.After the rabbit ear model was prepared,the random number table method was used to divide the model into acne mixture low,medium,and high dose groups,model groups,and drug control groups(isoretinoic acid pill),7 in each group,and the remaining 2 Used for modeling evaluation.After 2 weeks of treatme nt,the skin lesions of rabbit ears,histopathological changes under the microscope were observed with naked eyes,and the levels of TNF-α,IL-6,IL-1β,and testost erone in serum were detected by ELISA.Result:1 Clinical research(1)The total effective rate in the treatment group was 86.21%,of which 4 cas es were cured,15 cases were markedly effective,6 cases were effective,and 4 cas es were invalid;the total effective rate in the control group was 79.31%,3 cases were cured,14 cases were markedly effective,6 cases were effective,and 6 cases were invalid.The comprehensive clinical efficacy of the treatment group and the co ntrol group was equivalent(P>0.05),and the difference was not statistically signific ant.(2)After treatment,the skin symptom scores of the treatment group and the c ontrol group were significantly lower than before treatment(P<0.05).The scores of the skin symptom scores between the two groups were significantly better than tho se of the control group after treatment.(P> 0.05),but there was no significant diff erence.It shows that the two groups are equivalent in improving the main skin lesi ons such as pimples,pustules,nodules,and cysts.(3)After treatment,the scores of secondary symptoms of TCM both decreased after treatment,the treatment group decreased significantly(P<0.05),the control gr oup did not decrease significantly(P>0.05);Compared with the scores,the score of the treatment group was significantly better than that of the control group(P<0.05),the difference was statistically significant.It showed that the treatment group wa s significantly better than the control group in improving facial symptoms such as f lushing,bad breath,constipation,and yellow urine.(4)The skin symptom scores of the treatment group and the control group dec reased after 2 weeks,4 weeks,and 6 weeks,respectively,indicating that the cycleeffect of the two groups was significant during the treatment process(P<0.01);The comparison of the skin symptom scores between groups after 4 weeks,4 weeks,a nd 6 weeks(P> 0.05)indicates that the two groups of patients have comparable ef fects in the course of treatment.(5)One month after the end of treatment,follow-up found that 19 patients in the cured and markedly effective treatment group had 1 recurrence with a recurrenc e rate of 5.26%,and 17 patients in the cured and markedly effective control group had 7 relapses and a relapse rate of 41.18%.The treatment group was significantl y better than the control group in controlling the recurrence of the disease(P<0.05)(6)A total of 7 cases of mild adverse reactions occurred in the two groups of patients after using the drug,including 3 cases in the treatment group with an inc idence of 10.34% and 4 cases in the control group with an incidence of 13.79%.It showed that there was no significant difference in the incidence of adverse reactio ns during the treatment between the two groups.2 Animal experimental research(1)The total effective rate in the treatment group was 86.21%,of which 4 cas es were cured,15 cases were markedly effective,6 cases were effective,and 4 cas es were ineffective;the control group was 79.31%,of which 3 cases were cured,14 cases were markedly effective,and 6 cases were effective.6 cases were invalid.The comprehensive efficacy of the treatment group was significantly better than that of the control group(P<0.05),and the difference was statistically significant.(2)The scores of skin symptom scores in the two groups after treatment were significantly lower than before treatment(P<0.05);compared with the control grou p,the scores of skin symptom scores in the treatment group were slightly lower th an those in the control group(P> 0.05),but no significant difference.It shows th at the two groups have similar effects in treating the main skin lesions such as pi mples,pustules,nodules,and cysts.(3)After treatment,the scores of TCM secondary symptoms in both groups we re significantly lower than before treatment(P<0.05);compared with the treatmentgroup and the control group,the scores of skin lesion symptoms after treatment we re significantly lower in the treatment group than in the control group(P<0.05),the difference is statistically significant.It shows that the two groups are effective in t reating systemic symptoms such as facial flushing,bad breath,constipation,and yell ow urine,and the treatment group is more effective than the control group(P<0.05).(4)The evaluation of skin lesions in the two groups decreased at 2,4,and 6weeks after treatment,indicating that the cycle effect of the treatment group and th e control group was significant during the treatment process(P<0.01);Compared wi th the control group,the treatment group,the treatment group,the treatment group,the treatment group,and the control group had a similar decrease in the score of the skin lesions(P>0.05),indicating that there was no significant difference in the course of treatment between the treatment group and the control group.(5)One month after the end of treatment,it was found that 19 patients in the cured and markedly effective treatment group had a relapse,with a recurrence rate of 5.26%,and 17 patients in the cured and markedly effective control group had a relapse.The treatment group was significantly better than the control group in co ntrolling disease recurrence(P<0.05).(6)A total of 7 cases of mild adverse reactions occurred in the two groups aft er using the drug,in the treatment group of 3 cases,the incidence was 10.34%,an d in the control group of 4 cases,the incidence was 13.79%.It shows that the tre atment group and the control group have the same ability to control the occurrence of adverse reactions during the treatment process(P>0.05)Conclusion:Through clinical research,it has been shown that the overall efficacy of the two groups in treating lung and stomach fever-prone acne is equivalent,and th at the treatment group is better than the control group in its ability to improve syst emic symptoms and reduce the recurrence rate of TCM.Through animal experiment s,it has been found that the acne mixture can reduce The levels of blood-related i nflammatory factors and testosterone are dose-dependent.In summary,the acne mixture has a clear curative effect on acne without obvious toxic and side effects,and is worthy of clinical application. |
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