Clinical Observation Of Fire Acupuncture Combined With NB-UVB In The Treatment Of Stable Vitiligo With Qi And Blood Stasis Syndrome

Objective:To observe the changes in the area of white spots and the improvement of dermatological quality of life(DLQI)scores and TCM syndrome scores in patients with stable vitiligo,qi and blood stasis syndrome,and to evaluate the combination of fire acupuncture and narrow-band ultraviolet B(NB-UVB)Efficacy and safety of treatment of stable vitiligo,qi and blood stasis syndrome.Methods:80 cases meeting the inclusion criteria were randomly divided into a treatment group and a control group according to the random number table method.Both groups took the Bailing tablets(4 tablets each time,3 times a day)as the basic treatment.The treatment group used fire acupuncture(once every 2 weeks)combined with NB-UVB(initial dose of 0.3 J/cm~2,each increment of 0.1 J/cm~2,3 times a week)irradiation treatment,the control group received simple NB-UVB irradiation(same treatment group)treatment.The course of treatment in both groups was 12 weeks.The white spot area and adverse reactions were recorded at the 4th,8th,and 12th weeks of treatment.The DLQI score and TCM syndrome score were recorded before and after 12 weeks of treatment.Improve the situation to determine the efficacy,follow-up 8 weeks after the end of treatment to determine the recurrence.The data results were analyzed using SPSS 20.0 statistical software.Result:1.In this study,3 cases of shedding cases were excluded,77 cases were finally completed,39 cases in the treatment group and 38 cases in the control group.Baseline analysis was performed on the gender,age,course of disease,skin lesion area,white spot area,DLQI score,and TCM syndrome scores of the two groups of patients.The differences were not statistically significant(P>0.05)and clinically comparable.2.Comparison of clinical efficacy:After 4 weeks of treatment,the total effective rates of the treatment group and the control group were 76.92%and63.15%,respectively,with no significant difference(P>0.05).The white spot area of the two groups was significantly higher than the baseline period.Decreased(P<0.001),but there was no significant difference in the comparison of white spot area between the two groups(P>0.05);after 8weeks of treatment,the total effective rates of the treatment group and the control group were 82.05%and 68.42%,respectively.Statistically significant(P<0.05).The white spot area of the two groups was significantly reduced compared with 4 weeks after treatment(P<0.001).There was no significant difference in white spot area between the two groups(P>0.05).After 12weeks of treatment,The total effective rates of the treatment group and the control group were 89.74%and 76.32%,respectively,and the difference was statistically significant(P<0.05).The white spot area of the two groups was significantly reduced compared to 8 weeks after treatment(P<0.001).The area difference was also statistically significant(P<0.05).3.Analysis of the curative effect of the treatment group in different course of treatment after 12 weeks.The cure rates of those with disease course≤1 year,1 year<course≤3 years,and disease course>3 years were87.5%,71.42%,and 50%,respectively.There was a statistically significant difference in each course group(P<0.05).4.Analysis of the curative effect of different skin lesions in the treatment group after 12 weeks of treatment.The cure rates of face and neck,trunk,limbs,hands and feet were 100%,76.47%,42.86%,and 0%,respectively.There were statistics of differences in each group Significance(P<0.01).5.Comparison of improvement in DLQI scores and TCM syndrome scores:After 12 weeks of treatment,the DLQI scores and TCM syndrome scores of the two groups of patients decreased significantly(P<0.001),and the difference was also statistically significant between the two groups(P<0.001).Conclusion:Compared with NB-UVB irradiation alone,fire acupuncture combined with NB-UVB has better curative effect on stable vitiligo and qi and blood stasis syndrome,and significantly reduces the area of white spots,improves patients’quality of life and TCM symptoms,and has fewer adverse reactions The low recurrence rate deserves further clinical promotion.