| Objective: In this study,the method of retrospective analysis was used to analyze the clinical efficacy and safety of Jiuwei Chushi Granule in the treatment of central precocious puberty(Yin deficiency and fire flourishing syndrome)in female children,and to explore the pathogenesis characteristics,syndrome and treatment rules of precocious puberty in traditional Chinese medicine(TCM),so as to provide clinical reference for the better use of TCM in the treatment of precocious puberty.Methods :a total of 20 female children with central precocious puberty(Yin deficiency and fire flourishing syndrome)were selected for this study,they were treated in the growth and development outpatient department of Hubei Province Hospital of TCM from June,2018 to June,2019,and given Jiuwei Chushi granules orally,took 1 dose daily in 2 oral doses,three month is a course of treatment,and the drugs were stopped after 2 sessions.The method of retrospective analysis was adopted to analyze changes of clinical symptoms,TCM syndrome integral,the volume of uterus,ovarian volume,maximum follicle diameter,serum sex hormone levels(corpus luteum generated hormone,follicle-stimulating hormone,estradiol)and Tanner stage(B)among them before treatment,3months and 6 months after treatment,as well as change of bone age index before treatment and 6 months after treatment.All information and data had been recorded before and after treatment were analyzed with software SPSS24.0 in order to evaluate the clinical efficacy of Jiuwei Chushi Granule in the treatment of female children with central precocious puberty(Yin deficiency and fire flourishing syndrome).The liver function,renal function,blood analysis,urine analysis,electrocardiogram,five items of thyroid function and fasting blood glucose had been monitored before and after treatment,and the occurrence of adverse reactions was also counted to evaluate the safety of Jiuwei Chushi Granule.Results:1.Curative effect of TCM syndrome: clinical efficacy of 20 cases of central precocious puberty(Yin deficiency and fire flourishing syndrome)were analyzed,after 6 months of treatment,1 case was clinically recovered,8 cases with remarkable effect,7 cases were effective effect,and 4 cases with no curative effect,the total effective rate is up to 80%.2.Comparison of total score of TCM syndromes: compared with that before treatment,the total score of TCM syndromes decreased significantly after 3 months and 6 months of treatment,the difference was statistically significant(P<0.01).Compared with that of 3 months after treatment,the total score of TCM symptoms also decreased significantly after 6 months of treatment,the difference was statistically significant(P<0.01).3.Main symptom score and secondary symptom score of TCM symptoms: compared with that before treatment,the main symptom score and secondary symptom score decreased after 3 months and 6months of treatment,with statistically significant differences(P<0.05,P<0.01).After 6 months of treatment,the main symptom score and the secondary symptom score were also significantly lower than that before treatment,with statistically significant differences(P<0.01).Compared with 3 months after treatment,the main disease score and the secondary disease score significantly decreased after 6 months of treatment,with statistically significant differences(P<0.01).4.Comparison of breast stage(Tanner stage): before treatment,there were 0 cases in Tanner stage B1,11 in B2 period,9 in B3 and 0 in B4 period.3 months after treatment,Tanner stage B1 had 2 cases,B2 period 11 cases,B3 7 cases and B4 period 0case.After 6 months of treatment,among 20 cases,13 cases in stage B1,6 cases in B2,about 1 in B3 and 0 case in B4 period.5.Comparison of uterine and ovarian volume and maximum foll icle diameter: compared with before treatment,uterine and ovar ian volume and maximum follicle diameter all decreased slightly after 3 months of treatment,but the difference was not statis tically significant(P>0.05),while significantly decreased after6 months of treatment,with statistically significant differen ces(P<0.05).Compared with that of 3 months after treatment,the volume of uterus,ovary and maximum follicle diameter all decr eased significantly after 6 months of treatment,with statistic ally significant differences(P<0.05).6.Comparison of serum LH,FSH and E2: compared with before treatment,both LH and E2 decreased after 3 months of treatment,the difference was statistically significant(P<0.05,P<0.01),and FSH decreased compared with that before treatment,but the difference was not statistically significant(P>0.05).LH,FSH and E2 all decreased after 6 months of treatment compared with those before treatment,and the difference was statistically significant(P<0.05).Compared with 3 months of treatment,LH and E2 decreased,with no statistically significant difference(P>0.05),and FSH decreased,with statistically significant difference(P<0.05).7.Bone age index BA/CA: compared with that before treatment,BA/CA was slightly reduced after 6 months of treatment,with no statistically significant difference(P>0.05).8.Clinical safety: the liver function,renal function,blood analysis,urine analysis,electrocardiogram,five items of thyroid function and fasting blood glucose were all in the normal range during the treatment period among 20 cases of female children with central precocious puberty(Yin deficiency and fire flourishing syndrome),and no adverse reactions occurred during the treatment period among them.Conclusion:Jiuwei Chushi Granule has exactly clinical efficacy in the treatment of female children with central precocious puberty(Yin deficiency and fire flourishing syndrome),can improve clinical symptoms and TCM symptom integral,reduce Tanner stage,volume of uterus and ovaries as well as maximum follicle diameter;can lower serum LH,FSH,E2 levels.Besides,there is no adverse reaction among 20 cases of female children during the treatment period.All of above indicate that the treatment of Jiuwei Chushi Granule in female children with central precocious puberty(Yin deficiency and fire flourishing syndrome)is curatively effective and absolutely safe,and is worth further clinical research and application. |
PDF Full Text Request