| OBJECTIVE:This topic evaluates the effect of Bufei Huaji Decoction on the treatment of cancer-induced fatigue of advanced non-small cell lung cancer(positive deficiency virus nodule type).To observe the effect of Bufei Huaji Decoction on TCM syndromes and cancer fatigue scale scores in patients with advanced non-small cell lung cancer(positive deficiency poisoning type)cancer-related fatigueMethod:This project is to conduct clinical research on the improvement of cancer-related fatigue in patients with advanced non-small cell lung cancer(positive deficiency syndrome).Through the improvement of TCM syndromes and cancer-related fatigue.According to the inclusion exclusion criteria,patients who were admitted to the Oncology and Hematology Department of the Affiliated Hospital of Changchun University of Traditional Chinese Medicine from December 2018 to December 2019 were screened.The patients were included in the Cancer Fatigue Scale(CFS)score≥ 18 points,stage and The pathological classification should be in accordance with advanced(stage Ⅲb and stage Ⅳ)non-small cell lung cancer,and the TCM syndrome type is positive deficiency.A total of 60 patients with NSCLC who met the criteria for inclusion were collected.All patients had completed treatment and observation.During the experiment and follow-up,no cases of withdrawal and shedding occurredA prospective single-center randomized controlled research method was used to divide the eligible cases according to the random number table method into a treatment group and a control group.The treatment group was treated with Bufeihuaji decoction combined with Aidi injection,and the control group was treated with Aidi injection.On the 1st、16th and 34th day of admission,patients were diagnosed with TCM syndrome differentiation and CFS scale changes and improvement.Use statistical methods for analysisResults:A total of 60 patients completed the study.During the experiment,no cases of withdrawal and shedding occurred.After treatment,the total score of TCM syndromes in each group decreased.The total effective rate of the treatment group was 76.67%,and the total effective rate of the control group was 63.33%.The improvement of TCM syndromes in the treatment group was significantly better than that in the control group(P<0.05).Among the observed TCM syndromes,fatigue,weakness,shortness of breath,dry cough or phlegm,blood in the sputum,spontaneous sweating,sweating,loss of appetite,and shortness of breath and chest tightness were significantly improved.The test,P<0.05,was statistically different In terms of CFS scale score,both groups score decreased after treatment.the total score of the CFS scale score in the treatment group was 18.93±3.49,the body dimension score was (?)±S was 8.80±2.01,the emotion dimension score was (?)±S was 5.00±0.91,and the cognitive dimension was (?)±S is 5.13±1.48;the total score of the control group CFS scale is (?)±S is 25.93±4.66,the body dimension score is (?)± S is 11.90±2.22,the emotion dimension score is (?)±S is 7.47±2.08,and the cognitive dimension (?)±S is 6.57±1.68.The chi-square test was used for statistical data.The P values were all less than 0.05,and the differences were statistically significantConclusion:Bufeihuaji decoction has better clinical effect on the treatment of advanced non-small cell lung cancer tumor-associated fatigue.Compared with the application of Aidi injection,it has advantages in alleviating clinical symptoms of TCM and improving tumor-associated fatigue,and No obvious side effects,it is worth further promotion and application in clinical. |
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