Effect Of Enteral Nutrition In Patients With Esophageal Cancer After Radiotherapy And Chemotherapy

Objective To evaluate the effect of enteral nutrition(EN)on the efficacy,nutritional status and radiochemical side effects in patients with esophageal cancer after concurrent radiotherapy and chemotherapy.Methods Data of all esophageal cancer patients in Tianjin Hospital from January 2015 to January 2018 were collected systematically.According to discharge and inclusion criteria.Patients were randomly divided into two groups: nutrition group(enteral nutrition + radiotherapy and chemotherapy)and control group(simple radiotherapy and chemotherapy).In the control group,the dosage of DDP was 75mg/m2,intravenous drip,d1,5-FU 750 mg/m2,continuous intravenous drip d1-4,28 days a cycle and synchronous radiotherapy.Nutrition group was given 10-25 Kal /(kg.d)enteral nutrition on the basis of chemotherapy combined with radiotherapy.(1)Patients with mild obstruction or whose daily intake decreased by 0-33% were given enteral nutrition of 10-15 kcal /(kg d).(2)The patients with moderate obstruction or whose total daily food intake decreased by 33%-66% were given enteral nutrition of15-20 kcal /(kg d).(3)Intestinal nutrition of 20-25 kcal /(kg 65 The nutritional regimen was adjusted according to the patients’ diet,body weight and nutritional status.Finally,the nutritional indicators,efficacy and toxicity of radiotherapy and chemotherapy were observed.Results There was no significant difference in general condition,nutritional index(such as body weight change,hemoglobin,serum albumin,etc.)and PG-SGA score between nutrition group and control group before treatment.After treatment,the loss of body weight(2.44±0.31)kg in nutrition group was significantly less than that in control group(5.30±0.32)kg,the loss of hemoglobin(12.91±5.20)g/L and albumin(4.14±1.91)g/L in nutrition group was significantly less than that in control group(21.33±8.06 g/L;9.36±2.03 g/L),but the total lymphocyte count was not statistically significant.Significance.The objective remission rate was 83.3% in the nutrition group and 77.8% in the control group.There was no significant difference in the objective remission rate between the nutrition group and the control group(P >0.05).The blood toxicity of the nutrition group was significantly improved comparedwith that of the control group(31.1% vs.45.7%,P < 0.05).There was no significant difference in incidence of radiation esophagitis and acute radiation pneumonitis between the two groups(P > 0.05).Conclusions Enteral nutrition improves patients’ nutritional status,reduces weight loss of esophageal patients undergoing concurrent radiotherapy and chemotherapy,and improves their tolerance to radiotherapy and chemotherapy.