Clinical Observation Of "Wu Lao Qi Sun Decoction" In Wuwei Medical Bamboo Slips From Han Dynasty For Liver And Kidney Deficiencyof Ankylosing Spondylitis

Purpose:To observe the clinical efficacy and safety of“Wu Lao Qi Sun Decoction”in Wuwei medical bamboo slips from Han Dynasty for liver and kidney deficiencyof Ankylosing Spondylitis.and to provide a new way for clinical treatment of Ankylosing Spondylitis.Methods:According to the inclusion criteria,a total of 74 AS patients who visited the outpatient department and inpatient department of rheumatoid osteopathology in gansu provincial hospital of traditional Chinese medicine from January 2018 to December 2018 were included.They were randomly divided into the experimental group(n = 37)and the control group(n = 37).The control group was given conventional western medicine treatment:diclofenac sodium sustained-release capsule,50 mg,2 times/day and salazosulfopyridine enteric-coated tablet1.0g,2 times/day;Treatment in the experimental group in the control group on the basis of conventional treatment of western medicine plus the use of five Lao qi su fang.Both groups were treated for 12 weeks.Test efficacy in the treatment of 12 weeks before and after treatment,respectively on two groups of patients with TCM syndrome integral,the pain at night and spinal pain,pillow wall distance,refers to the ground,the Schober test distance,thoracic mobility,The Bath Ankylosing Spondylitis disease activity Index(BASDAI),The Bath Ankylosing Spondylitis functional Index(BASFI),Bath AS measurement index(BASMI),blood sedimentation(ESR),C-reactive protein(CRP)and the research of safety evaluation.In this experiment,SPSS 20.0 software was used for statistical analysis.P<0.05 was considered as the standard for determining whether there was statistical significance.(1)all measurement data conforming to the normal distribution were expressed as mean standard deviation,and paired t test was used for comparison before and after treatment.(2)frequency and ratio were used for statistical description of the counting data,and 2 2 table 2 test was used for comparison between the two groups.The rank sum test was used to analyze the data that did not conform to the normal distribution.Results:(1)In terms of the efficacy of TCM syndromes: of the 37 patients in the experimentalgroup,5 were cured,18 were significantly effective,9 were effective,and the total effective rate was 86.49%;Among the 37 patients in the control group,2 cases were cured,15 cases showed significant effect,6 cases were effective,and the total effective rate was62.16%.After statistical analysis,the difference between the two groups was statistically significant(P < 0.05).The experimental group was significantly better than the control group(P < 0.01)in improving the patients’ back,waist,hip and hip pain,morning stiffness,limited activities of waist and spine,soft waist and knee,dizziness and tinnitus,and night pain.(2)In terms of ASAS20 efficacy criteria: among the 37 patients in the experimental group,33 patients with ASAS20 were up to standard,and 4 patients with ASAS20 were not up to standard.The effective rate was 89.19%.Among the 37 patients in the control group,there were 23 cases with ASAS20 successful bidder and 14 cases without successful bidder,with an effective rate of 62.16%.After statistical analysis,the difference between the two groups was statistically significant,and the effective rate of the experimental group was significantly better than that of the control group(P < 0.01).(3)Both treatment methods could improve patients’ night pain and spinal pain VAS score(P < 0.05),but the improvement degree of the experimental group was significantly better than that of the control group(P < 0.01).(4)The two groups of treatment methods for the patient’s pillow wall distance,refers to the ground distance,chest activity,Schober were improved(P < 0.05).The experimental group was significantly better than the control group(P < 0.01)in reducing the distance between the pillow wall and the finger ground,increasing the range of motion of the chest and improving the Schober test.(5)BASDAI,BASFI and BASMI scores were improved in both groups(P < 0.05).The experimental group was significantly better than the control group in improving BASDAI,BASFI and BASMI scores(P < 0.01).(6)The two groups of treatment methods can reduce ESR,CRP value(P <0.05).However,the reduction of ESR and CRP in the experimental group was significantly better than that in the control group(P < 0.01).(7)The incidence of adverse reactions in the experimental group was lower than that in the control group(P < 0.05).Conclusion:"Wu Lao Qi Sun Decoction" in Wuwei medical bamboo slips from Han Dynasty can significantly improve the liver and kidney deficiency type of Ankylosing Spondylitis patients pain and restricted movement function,lumbar debility,dizziness,tinnitus and other syndromes,can significantly improve the AS pillow wall distance,refers to the distance,in patients with thoracic mobility,Schober,BASDAI and BASFI,BASMI score,reduce the ESR and CRP values,and security is good,can be used AS a clinical treatment of liver and kidney deficiency type AS an effective method.