Clinical Study On The Treatment Of Ankylosing Spondylitis With Kidney Deficiency Of Liver By Jideshu Decoction

Objective:Guided by traditional Chinese medicine theory,the study observed certain indicators including the BATH score,BASFI score,PGA score and general VAS,activity degree of cervical spine,Lateral flexion of lumbar spine,inflammation index,TCM symptom score etc,which are produced from the ankylosing spondylitis(AS)patients of liver and kidney deficiency type treated by Jideshu decoction.Then the indicators are used to compare with the control group to evaluate the efficacy of Jideshu decoction.Methods:60 selected AS patients from outpatient or ward from rheumatism department of Henan Province Hospital Of TCM from April 2017 to February 2018.After they were randomly divided into 2 groups,in the treatment group,sulfasalazine and enteric-coated tablets were combined with celecoxib capsules,while in the control group,Jideshu decoction was taken orally on the basis of the control group.The change of the observation index before and after taking Jideshu decoction is recorded to evaluate the efficacy and safety of the medicine and compare the efficacy and safety with the control group.Results: 1.Comparing the index of CRP and ESR in the treatment group with the control group,there was a significantly statistical difference between the two indexes from two-moth treatment and six-month treatment compared with the value before treatment(P < 0.05).After 3 months and 6 months of treatment,the CRP and ESR index of the two groups of patients decreased significantly,and the statistical difference was significant(P<0.05).2.After 3 months and 6 months of treatment,the BATH score,BASFI score,PGA score and general VAS of the two groups were significantly improved compared with those before treatment.The statistical difference was significant between the two groups(P<0.05).3.In the treatment group after the 3 months and 6 months of treatment,the BATH score,BASFI score,PGA score and general VAS were not significantly different from the control group(P >0.05).4.In the TCM syndrome clinical evaluation,the total effective rate of thetreatment group was 90%,which was better than that of the control group 83.3%,and the statistical difference was not significant(P > 0.05);in the ASAS20 efficacy evaluation,the total effective rate of the treatment group was 80%,which was better than 63.3% of the control group,and the statistical difference was significant(P <0.05).The difference of the latter groups was more significant.5.During the experiment,the two groups of patients have stable vital life signs,one patient in the treatment group experienced mild diarrhea symptoms,while in the control group,four patients experienced symptoms of nausea and vomiting,and liver and kidney function were not significantly abnormal.Conclusion: The treatment of Jideshu decoction of AS(liver and kidney deficiency type)can significantly alleviate the symptoms,reduce the inflammatory indicators,improve the activity degree,and reduce the scores of TCM syndromes with high safety and significant efficacy.The treatment of AS by Western medicine is mainly based on oral administration of drugs.The side effects are relatively large and the price is expensive,which is not conducive to long-term use.The results of the study show that Jideshu decoction combined with western medicine can not only enhance efficacy,but also may reduce adverse reactions and side effects.Therefore,Jideshu decoction is worth exploring further.However,due to the short observation time and limited sample size,the long-term efficacy of Jideshu decoction should be further observed.