Clinical Characteristics And Prognostic Factors Of Extensive Small Cell Lung Cancer

Objective: The related clinical features and treatment of 175 patients with extensive small-cell lung cancer were retrospectively analyzed to explore the related factors influencing the prognosis,so as to guide the prognosis evaluation of extensive small-cell lung cancer.Methods: The clinical data of patients with extensive SCLC at the Liaoning Provincial Tumor Hospital between March 1,2011 and March 1,2016 were collected.The final follow-up period was March 31,2018.SPSS22.0 soft ware was used for statistical analysis.Kaplan-Meier method was used for survival analysis.COX regression model was used for multivariate analysis.Test level α=0.05.The end of the observation was death or follow-up.Results: The survival time of the whole group of 175 patients was 5.8-62 months.The median survival time was 14.3 months.The one-,two-,and three-year survival rates were 60.6%,28.6%,and 10.2%,respectively.Univariate analysis suggested that bone metastasis,hepatic metastasis,serum CEA,NSE,CYFRA21-1 levels,efficacy of first-line chemotherapy,number of first-line chemotherapy cycles,whether to receive thoracic radiotherapy,and PCI were the prognostic factors of extensive small cell lung cancer.COX multivariate analysis suggested that liver metastasis and first-line chemotherapy cycles were ≥4,and the first-line chemotherapy effect was CR.Chest radiotherapy is an independent factor for the prognosis of extensive stage small cell lung cancer.Liver metastasis is a risk factor for prognosis.The number of first-line chemotherapy cycles is ≥4.The first-line chemotherapy has a CR effect,and chest radiotherapy is a protective factor.Conclusions: The number of first-line chemotherapy cycles is ≥4.The first-line chemotherapy has a CR effect.Patients undergoing chest radiotherapy have a better prognosis.The initial treatment with liver metastasis indicates a poor prognosis.