Serum Asprosin Level In Patients With Metabolic Syndrome And Coronary Heart Disease And Its Correlation With Metabolic Indicators

ObjectiveAsprosin is a novel adipokine secreted by white fat,which can rapidly induce glucose production and regulate the release of glucose from the liver.Hyperglycemia and obesity are important components of metabolic syndrome and high risk factors for coronary heart disease.However,it is not clear whether asprosin is related to metabolic syndrome(MS)and coronary heart disease(CHD).Therefore,this study aims to explore the relationship between Asprosin and metabolic syndrome and coronary heart disease by comparing the differences of serum Asprosin between patients with non-metabolic syndrome and patients with metabolic syndrome,and between patients with non-coronary heart disease and coronary heart disease,so as to provide diagnosis and treatment for metabolic syndrome and coronary heart disease.MethodFrom January 2016 to September 2017,135 patients with chest distress who underwent coronary angiography in the Department of Cardiology of our hospital were selected as the study subjects.68 patients with coronary heart disease and 67 patients with non-coronary heart disease diagnosed by coronary angiography(CAG)were selected from January 2016 to April 2018.According to the diagnostic criteria of metabolic syndrome(MS)of the Chinese Medical Association Diabetes Branch in2004,62 patients with metabolic syndrome and 73 patients with non-metabolic syndrome were divided into two groups.The basic parameters of all subjects were measured uniformly.Biochemical indexes such as liver function,kidney function,blood lipid and fasting blood sugar were measured.Gensini scoring system was used to evaluate the results of CAG.Serum asprosin levels were measured by ELISA.Independent sample t test,rank sum test,linear correlation and multiple linear regression analysis were used for statistical analysis.Logistic regression was used to analyze the relationship between the relative risk of MS and coronary heart disease and asprosin level.Result(1)Serum asprosin level in MS group was significantly higher than that in non-MS group(P < 0.01).Compared with non-MS group,body mass index(BMI),serum uric acid(UA),total cholesterol(TC),FPG and Genesini scores in MS group were significantly increased(P < 0.05 or P < 0.01),HDL-C level decreased(P < 0.01),and the proportion of coronary heart disease increased(P < 0.01).(2)Serum asprosin level in CHD group was significantly higher than that in non-CHD group(P < 0.01).Compared with non-CHD group,age,UA,triglyceride(TG),FPG and Gensini scores in CHD group were significantly increased(P < 0.05 or P < 0.01),high density lipoprotein-cholesterol(HDL-C)level was lower(P < 0.01),and the prevalence of MS was significantly higher(P < 0.01).(3)Serum asprosin level was the highest in MS combined with CHD group and the lowest in control group.There was no significant difference between the two groups in the level of asprosin in patients with MS or CHD only.(4)The subjects were divided into three groups according to the level of serum asprosin: low level asprosin,medium level asprosin and high level asprosin.There were differences in height,UA,FPG,TG and Genesini scores among the three groups.With the increase of serum asprosin level,the prevalence of coronary heart disease(31.3%,53.3%,66.7%)and MS(26.7%,46.7%,64.4%)also increased.Gensini score also increased with the increase of serum asprosin level.(5)All subjects were grouped according to the number of MS risk factors.Serum asprosin increased with the increase of MS components.(6)The correlation analysis showed that serum asprosin levels were positively correlated with TG,UA,FPG and Gensini scores(P < 0.05 or P < 0.01).(7)With serum asprosin level as dependent variable,BMI,systolic blood pressure,diastolic blood pressure,creatinine,urea nitrogen,UA,AST,ALT,HDL-C,LDL-C,TC,TG,FPG and Genesini scores as independent variables were stepwise regression.FPG(? = 0.363,P < 0.01)and TG(? = 0.264,P < 0.01)entered the equation.(8)The occurrence of MS was taken as dependent variable,Asprosin triple,LDL-C,TC,UA triple,gender and age were taken as independent variables for logistic regression analysis.High levels of uric acid and Asprosin increased the risk of MS.(9)Regarding whether MS combined with CHD as dependent variable,Logistic regression analysis was performed with asprosin triple,LDL-C,TC,UA triple,gender and age as independent variables.The results suggest that age,and high levels of asprosin increase the risk of MS combined with CHD.conclusion(1)Serum asprosin levels were significantly increased in MS patients,which was significantly correlated with MS and its components.(2)The serum asprosin level in MS patients with CHD was significantly increased,which was positively correlated with Gensini score,FPG and TG.(3)With the increase of serum asprosin level,the risk of MS and CHD increased gradually.Serum asprosin levels were positively correlated with TG,UA,FPG and Gensini scores.It suggests that Asprosin may be related to the occurrence and development of MS and CHD.