| Objectives To observe the clinical effect of professor zhao yan’s empirical prescription “modified xiaoyao powder”combined with letrozole in the treatment of anovulatory infertility due to stagnation of liver-qi and the changes of hormone levels.Periodic intervention of the patients will To provide more clinical thinking for the treatment of anovulatory infertility due to stagnation of liver-qi by combination of traditional Chinese medicine and western medicine,and to reduce the phenomenon of "high ovulation and low fertility" of letrozole alone.Methods In this study,patients with complete data from the gynecological outpatient department of shijiazhuang traditional Chinese medicine hospital due to female infertility between October 2017 and November 2018 were collected by statistical method of random numbering.All the cases meet the diagnostic criteria ofanovulatory infertility due to stagnation of liver-qi.A total of 64 cases were selected: Thirty-two patients were treated with “ modified xiaoyao powder ” combined with letrozole.Thirty-two patients were treated with letrozole as control group.The treatment duration was 3 menstrual cycles,Clinical symptoms,the changes of endometrial thickness,follicular size,and hormone levels were compared between the two groups.Spss23.0 was used for statistical analysis of the collected data.The treatment group and the control group were first tested for test distribution.Nonparametric tests are used for data that do not satisfy the test distribution.The counting data were tested by chi-square test.Rank sum test was used for rank data that did not satisfy the test distribution.Results A total of 64 cases were selected,including 32 cases in the treatment group(2 cases of abscission: including 1 case of abscission due to diabetes mellitus during treatment and 1 case of abscission due to interruption of treatment).Thirty-two patients were enrolled in the control group(2 cases were exfoliated: One case fell off due to discontinued treatment.One case was discontinued due to other treatment)The data of the two groups before treatment were comparable(P>0.05),Through this study included in 60 cases of anovulatory infertility due to stagnation of liver-qi,after three menstrual cycles treatment,the results are as follows:(1)Results of the overall rate: the total effective rate in the control group was 80% significantly lower than that in the treatment group(93.34%),there were significant difference(P<0.05).(2)Comparison of syndrome score: the overall syndrome score of the two groups of patients was compared,and the results showed that both of them were lower than before treatment(P<0.05).The treatment group(9.883±1.448)was significantly lower than the control group(14.963±2.090)(P<0.05),which was of statistical significance,indicating that“modified xiaoyao powder”combined with letrozole in the treatment of anovulatory infertility due to stagnation of liver-qi had a more integrated regulatory effect.(3)Comparison of the effect on the serum level of FSH,LH and endometrial thickness: after treatment,hormone levels in each group were improved compared with those before treatment(all P <0.05),and endometrial thickness in the treatment group(8.280±1.011mm)was significantly greater than that in the control group(6.897±1.093mm).The results indicated that the hormone level in the treatment group had a good effect on improving the intrauterine environment.(4)Comparison of follicular diameter: after treatment,both groups showed improvement(P <0.05),with statistical significance.after treatment,the maximum follicular diameter of the treatment group was 19.710±1.595 mm.which was significantly superior to the control group’s18.138±2.310 mm.(5)Comparison of ovulation status: after treatment,ovulation rate of the treatment group was 84.44% better than that of the control group was 77.78%,Chi-square tests show there is no significcant differences(P>0.05).(6)Comparison of pregnancy status: after treatment,pregnancy rate(53.34%)in the treatment group was significantly higher than that in the control group(26.67%).there were significant difference(P<0.05).Conclusions 1.In improving clinical symptoms,such asthe serum level of FSH,LH,endometrial thickness and follicular diameter.2.“ modified xiaoyao powder ”combined with letrozole in the treatment of anovulatory infertility due to stagnation of liver-qi can improve the pregnancy rate and reduce the phenomenon of "high ovulation and low fertility" of letrozole alone.Figure0;Table8;Reference 99. |
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