| PURPOSE:The purpose of this article is to observe the clinical effect of two treatment methods on gastrointestinal heat accumulation syndrome of Henoch-Schonlein purpura(skin type).These two treatments are the Purpura Decoction and the Purpura Granules.Under the research and observation,this study can provide new ideas and basis for the treatment of Henoch-Schonlein purpura(skin type)for patients to choose traditional Chinese medicine dosage forms.METHOD:This study selected 120 children in our hospital.All of these suffered form allergic purpura with mid-gastrointestinal pyrexia syndrome.60 cases in each group were randomly divided into decoction group and granules group.Depending on the age and weight of the child,the decoction group and granules group were given corresponding doses of the Purpura Decoction and the Purpura Granules.The children were treated for 28 consecutive days.After the treatment,we can compare the efficacy of intra-group and inter-group treatment for primary and secondary symptom.In the above way,Gastrointestinal Purpura decoction can be proved to be effective.It is also possible to compare the efficacy of two dosage forms.After three months of follow-up,these children could be assessed for recurrence rates.RESULT:1.The baseline to compare:There was no significant difference in gender,age,course of disease and other aspects between the two groups(p>0.05).So it is comparable 2.The symptoms of the two groups were compared before and after treament:There was no statistical difference in scores of syndromes before treatment between the two groups(P<0.05).So it is comparable.3.Comparison of curative effect of two groups of symptoms: Within the two groups were compared before and after treatment,the results showed that the two groups had significant effect in improving the main symptoms of skin rash and the color of skin rash in children(P<0.01).It also has obvious curative effect on secondary symptoms such as molar,halitosis,abdominal distension,sweating,constipation,thirst and drinking,fever of hands and feet,restlessness at night.4.Between the two groups were compared before and after treatment.The two groups had obvious effects in improving the main symptoms of skin rash and skin rash color,secondary symptoms of molars,halitosis,abdominal distension,sweating,constipation,thirst and drinking,hand-foot-heart fever and restlessness at night(P>0.05).5.The comparison of efficacy evaluation:(1)TCM syndrome effet:In the Decoction group,36 cases were cured,24 cases were markedly effective,0cases were effective and 0 cases were ineffective.The more explicit rate was 60%,the total effective rate was 100%.In the Granules group,28 cases were cured,32 cases were markedly effective,0 cases were effective and 0 cases were ineffective.The more explicit rate was 46.67%,the total effective rate was 100%.P>0.05 means that there is no significant difference in clinical therapeutic effect between the two groups.(2)Evaluation of disease efficacy: Clinical remission rate of decoction group and granules group are 38.3% and 40%,all the cure rates are 100%.The comparisons between the two groups is P>0.05.Therefore,there is no difference in the curative effect between the two groups.6.The comparison of the recurrence rate of skin rash: The recurrence rate was 18.96% in Decoction group and 22.41% in Granule group.P>0.05 means that there is no statistical difference between the two groups in the prevention of rash recurrence.7.Security index: No obvious toxic and side effects were found in the clinical application between the two dosage forms of gastrointestinal purpura decoction by safety index test.CONCLUSION:Gastrointestinal purpura Decoction and Granules in the treatment of children with allergic purpura of skin type(gastrointestinal heat accumulation syndrome)have significant clinical efficacy.There is no difference in clinical efficacy between the two groups.They are not only safe to use,but also effective in preventing the recurrence of skin rash. |
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