Association Between Ambient PM2.5 Exposure And Increased COPD Risk

Chronic obstructive disease is an illness characterized by obstruction of the airflow which is not wholly reversible.COPD is estimated to constitute a heavy burden on the public health due to its relation with a high economic cost,an increased morbidity and mortality.It is known to have a unique causal factor,cigarette smoking,but the significant group of COPD patients who are non-smokers cannot be justified by this factor.One of the risk factors of the onset of COPD and exacerbation of COPD to be rising is the outdoor air pollution in a general manner and PM2.5 in particular.A systematic review and meta-analysis were carried out as one part of our work in order to provide more understanding on the matter of association between PM2.5 exposure and COPD with the focus on short-term exposure to PM2.5 and COPD hospitalizations.As a second part of our work,we introduced a panel study which had the goal of assessing inflammatory metabolite levels associated with exposure to DEP.The search identified 12 studies that were relevant to our topic for the meta-analysis from1997-2017.A 10?g/m3 of PM 2.5 was associated with OR=1.055(95% CI= 1.034-1.076)with evidence of heterogeneity and no publication bias.The panel study demonstrated that an increase of 1-NP metabolite levels correlated with a high level of IL-6 in COPD patients.From the search and the studies conducted,our results from the meta-analysis suggest that an exposure to PM2.5 is associated with increased COPD hospitalizations while the panel study suggests that COPD patients are more susceptible when exposed to DEP.